1rk8

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[[Image:1rk8.gif|left|200px]]
[[Image:1rk8.gif|left|200px]]
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{{Structure
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|GENE= tsu ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster]), MAGO,MGN,CG9401 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster]), WIBG,PYM,CG30176/CG10330 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster])
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{{STRUCTURE_1rk8| PDB=1rk8 | SCENE= }}
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|RELATEDENTRY=[[1hl6|1HL6]], [[1oo0|1oo0]], [[1p27|1P27]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rk8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rk8 OCA], [http://www.ebi.ac.uk/pdbsum/1rk8 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1rk8 RCSB]</span>
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'''Structure of the cytosolic protein PYM bound to the Mago-Y14 core of the exon junction complex'''
'''Structure of the cytosolic protein PYM bound to the Mago-Y14 core of the exon junction complex'''
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[[Category: Guettler, T.]]
[[Category: Guettler, T.]]
[[Category: Izaurralde, E.]]
[[Category: Izaurralde, E.]]
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[[Category: mrna processing]]
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[[Category: Mrna processing]]
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[[Category: nmd]]
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[[Category: Nmd]]
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[[Category: oskar mrna localization]]
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[[Category: Oskar mrna localization]]
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[[Category: rbd]]
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[[Category: Rbd]]
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[[Category: rrm]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:35:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:29:17 2008''
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Revision as of 04:35, 3 May 2008

Image:1rk8.gif

Template:STRUCTURE 1rk8

Structure of the cytosolic protein PYM bound to the Mago-Y14 core of the exon junction complex


Overview

The exon junction complex (EJC) is deposited on mRNAs as a consequence of splicing and influences postsplicing mRNA metabolism. The Mago-Y14 heterodimer is a core component of the EJC. Recently, the protein PYM has been identified as an interacting partner of Mago-Y14. Here we show that PYM is a cytoplasmic RNA-binding protein that is excluded from the nucleus by Crm1. PYM interacts directly with Mago-Y14 by means of its N-terminal domain. The crystal structure of the Drosophila ternary complex at 1.9 A resolution reveals that PYM binds Mago and Y14 simultaneously, capping their heterodimerization interface at conserved surface residues. Formation of this ternary complex is also observed with the human proteins. Mago residues involved in the interaction with PYM have been implicated in nonsense-mediated mRNA decay (NMD). Consistently, human PYM is active in NMD tethering assays. Together, these data suggest a role for PYM in NMD.

About this Structure

1RK8 is a Protein complex structure of sequences from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Molecular insights into the interaction of PYM with the Mago-Y14 core of the exon junction complex., Bono F, Ebert J, Unterholzner L, Guttler T, Izaurralde E, Conti E, EMBO Rep. 2004 Mar;5(3):304-10. Epub 2004 Feb 13. PMID:14968132 Page seeded by OCA on Sat May 3 07:35:56 2008

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