5ucm
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of Prolyl-tRNA Synthetase from Pseudomonas aeruginosa== | |
| - | + | <StructureSection load='5ucm' size='340' side='right' caption='[[5ucm]], [[Resolution|resolution]] 2.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5ucm]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UCM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UCM FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Proline--tRNA_ligase Proline--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.15 6.1.1.15] </span></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ucm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ucm OCA], [http://pdbe.org/5ucm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ucm RCSB], [http://www.ebi.ac.uk/pdbsum/5ucm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ucm ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SYP_PSEAE SYP_PSEAE]] Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Proline--tRNA ligase]] | ||
| + | [[Category: Structural genomic]] | ||
| + | [[Category: Ligase]] | ||
| + | [[Category: Proline-trna ligase]] | ||
| + | [[Category: Pror]] | ||
| + | [[Category: Ssgcid]] | ||
Revision as of 01:43, 11 March 2017
Crystal Structure of Prolyl-tRNA Synthetase from Pseudomonas aeruginosa
| |||||||||||
