1gpw
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:1gpw.gif|left|200px]]<br /> | + | [[Image:1gpw.gif|left|200px]]<br /><applet load="1gpw" size="450" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1gpw" size="450" color="white" frame="true" align="right" spinBox="true" | + | |
caption="1gpw, resolution 2.40Å" /> | caption="1gpw, resolution 2.40Å" /> | ||
'''STRUCTURAL EVIDENCE FOR AMMONIA TUNNELING ACROSS THE (BETA/ALPHA)8 BARREL OF THE IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE BIENZYME COMPLEX.'''<br /> | '''STRUCTURAL EVIDENCE FOR AMMONIA TUNNELING ACROSS THE (BETA/ALPHA)8 BARREL OF THE IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE BIENZYME COMPLEX.'''<br /> | ||
| Line 8: | Line 7: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1GPW is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima] with PO4 as [http://en.wikipedia.org/wiki/ligand ligand]. | + | 1GPW is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima] with PO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=PO1:Binding Site For Po4 P6'>PO1</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GPW OCA]. |
==Reference== | ==Reference== | ||
| Line 25: | Line 24: | ||
[[Category: histidine biosynthesis]] | [[Category: histidine biosynthesis]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 15:29:21 2007'' |
Revision as of 13:19, 18 December 2007
|
STRUCTURAL EVIDENCE FOR AMMONIA TUNNELING ACROSS THE (BETA/ALPHA)8 BARREL OF THE IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE BIENZYME COMPLEX.
Overview
Since reactive ammonia is not available under physiological conditions, glutamine is used as a source for the incorporation of nitrogen in a, number of metabolic pathway intermediates. The heterodimeric ImGP synthase, that links histidine and purine biosynthesis belongs to the family of, glutamine amidotransferases in which the glutaminase activity is coupled, with a subsequent synthase activity specific for each member of the enzyme, family. Its X-ray structure from the hyperthermophile Thermotoga maritima, shows that the glutaminase subunit is associated with the N-terminal face, of the (beta alpha)(8) barrel cyclase subunit. The complex reveals a, putative tunnel for the transfer of ammonia over a distance of 25 A., Although ammonia tunneling has been reported for glutamine, amidotransferases, the ImGP synthase has evolved a novel mechanism, which, extends the known functional properties of the versatile (beta alpha)(8), barrel fold.
About this Structure
1GPW is a Protein complex structure of sequences from Thermotoga maritima with PO4 as ligand. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Structural evidence for ammonia tunneling across the (beta alpha)(8) barrel of the imidazole glycerol phosphate synthase bienzyme complex., Douangamath A, Walker M, Beismann-Driemeyer S, Vega-Fernandez MC, Sterner R, Wilmanns M, Structure. 2002 Feb;10(2):185-93. PMID:11839304
Page seeded by OCA on Tue Dec 18 15:29:21 2007
