5mlt
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mlt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mlt OCA], [http://pdbe.org/5mlt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mlt RCSB], [http://www.ebi.ac.uk/pdbsum/5mlt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mlt ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mlt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mlt OCA], [http://pdbe.org/5mlt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mlt RCSB], [http://www.ebi.ac.uk/pdbsum/5mlt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mlt ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Streptococcus pneumoniae is an opportunistic respiratory pathogen that remains a major cause of morbidity and mortality globally, with infants and the elderly at the highest risk. S. pneumoniae relies entirely on carbohydrates as a source of carbon and dedicates a third of all uptake systems to carbohydrate import. The structure of the carbohydrate-free substrate-binding protein SP0092 at 1.61 A resolution reveals it to belong to the newly proposed subclass G of substrate-binding proteins, with a ligand-binding pocket that is large enough to accommodate complex oligosaccharides. SP0092 is a dimer in solution and the crystal structure reveals a domain-swapped dimer with the monomer subunits in a closed conformation but in the absence of carbohydrate ligand. This closed conformation may be induced by dimer formation and could be used as a mechanism to regulate carbohydrate uptake. | ||
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| + | Structural characterization of the Streptococcus pneumoniae carbohydrate substrate-binding protein SP0092.,Culurgioni S, Tang M, Walsh MA Acta Crystallogr F Struct Biol Commun. 2017 Jan 1;73(Pt 1):54-61. doi:, 10.1107/S2053230X16020252. Epub 2017 Jan 1. PMID:28045395<ref>PMID:28045395</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 5mlt" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 16:17, 25 January 2017
Structural characterization of a carbohydrate substrate binding protein from Streptococcus pneumoniae
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