1rqf

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1rqf.gif|left|200px]]
[[Image:1rqf.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1rqf |SIZE=350|CAPTION= <scene name='initialview01'>1rqf</scene>, resolution 2.89&Aring;
+
The line below this paragraph, containing "STRUCTURE_1rqf", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=UNK:UNKNOWN'>UNK</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE= KC2B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8355 Xenopus laevis])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1rqf| PDB=1rqf | SCENE= }}
-
|RELATEDENTRY=[[1qf8|1QF8]], [[1jwh|1JWH]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rqf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rqf OCA], [http://www.ebi.ac.uk/pdbsum/1rqf PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1rqf RCSB]</span>
+
-
}}
+
'''Structure of CK2 beta subunit crystallized in the presence of a p21WAF1 peptide'''
'''Structure of CK2 beta subunit crystallized in the presence of a p21WAF1 peptide'''
Line 34: Line 31:
[[Category: Pei, X Y.]]
[[Category: Pei, X Y.]]
[[Category: Sayed, M F.]]
[[Category: Sayed, M F.]]
-
[[Category: casein kinase beta subunit]]
+
[[Category: Casein kinase beta subunit]]
-
[[Category: cyclin-dependent kinase inhibitor]]
+
[[Category: Cyclin-dependent kinase inhibitor]]
-
[[Category: ser/thr protein kinase]]
+
[[Category: Ser/thr protein kinase]]
-
[[Category: zn finger]]
+
[[Category: Zn finger]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:47:28 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:31:36 2008''
+

Revision as of 04:47, 3 May 2008

Image:1rqf.gif

Template:STRUCTURE 1rqf

Structure of CK2 beta subunit crystallized in the presence of a p21WAF1 peptide


Overview

A truncated form of the regulatory subunit of the protein kinase CK2beta (residues 1-178) has been crystallized in the presence of a fragment of the cyclin-dependent kinase inhibitor p21WAF1 (residues 46-65) and the structure solved at 2.9 A resolution by molecular replacement. The core of the CK2beta dimer shows a high structural similarity with that identified in previous structural analyses of the dimer and the holoenzyme. However, the electron density corresponding to the substrate-binding acidic loop (residues 55-64) indicates two conformations that differ from that of the holoenzyme structure [Niefind et al. (2001), EMBO J. 20, 5320-5331]. Difference electron density near the dimerization region in each of the eight protomers in the asymmetric unit is attributed to between one and eight amino-acid residues of a complexed fragment of p21WAF1. This binding site corresponds to the solvent-accessible part of the conserved zinc-finger motif.

About this Structure

1RQF is a Single protein structure of sequence from Xenopus laevis. Full crystallographic information is available from OCA.

Reference

Structure of the regulatory subunit of CK2 in the presence of a p21WAF1 peptide demonstrates flexibility of the acidic loop., Bertrand L, Sayed MF, Pei XY, Parisini E, Dhanaraj V, Bolanos-Garcia VM, Allende JE, Blundell TL, Acta Crystallogr D Biol Crystallogr. 2004 Oct;60(Pt 10):1698-704. Epub, 2004 Sep 23. PMID:15388915 Page seeded by OCA on Sat May 3 07:47:28 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1rqf"
Personal tools