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1rti

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[[Image:1rti.jpg|left|200px]]
[[Image:1rti.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1rti |SIZE=350|CAPTION= <scene name='initialview01'>1rti</scene>, resolution 3.0&Aring;
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The line below this paragraph, containing "STRUCTURE_1rti", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CYA:TWO+OXYGEN+ATOMS+BOUND+TO+SG+OF+CYS'>CYA</scene>, <scene name='pdbligand=HEF:1-(2-HYDROXYETHYLOXYMETHYL)-6-PHENYL+THIOTHYMINE'>HEF</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= HIV-1 POL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])
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-->
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|DOMAIN=
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{{STRUCTURE_1rti| PDB=1rti | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rti FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rti OCA], [http://www.ebi.ac.uk/pdbsum/1rti PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1rti RCSB]</span>
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}}
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'''HIGH RESOLUTION STRUCTURES OF HIV-1 RT FROM FOUR RT-INHIBITOR COMPLEXES'''
'''HIGH RESOLUTION STRUCTURES OF HIV-1 RT FROM FOUR RT-INHIBITOR COMPLEXES'''
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[[Category: Stammers, D.]]
[[Category: Stammers, D.]]
[[Category: Stuart, D.]]
[[Category: Stuart, D.]]
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[[Category: hiv-1 reverse transcriptase]]
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[[Category: Hiv-1 reverse transcriptase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:53:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:32:41 2008''
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Revision as of 04:53, 3 May 2008

Image:1rti.jpg

Template:STRUCTURE 1rti

HIGH RESOLUTION STRUCTURES OF HIV-1 RT FROM FOUR RT-INHIBITOR COMPLEXES


Overview

We have determined the structures of four complexes of HIV-1 reverse transcriptase with non-nucleoside inhibitors, three fully refined at high resolution. The highest resolution structure is of the RT-nevirapine complex which has an R-factor of 0.186 and a root-mean-square bond length deviation of 0.015 A for all data to 2.2 A. The structures reveal a common mode of binding for these chemically diverse compounds. The common features of binding are largely hydrophobic interactions and arise from induced shape complementarity achieved by conformational rearrangement of the enzyme and conformational/configurational rearrangement of the compounds.

About this Structure

1RTI is a Protein complex structure of sequences from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

High resolution structures of HIV-1 RT from four RT-inhibitor complexes., Ren J, Esnouf R, Garman E, Somers D, Ross C, Kirby I, Keeling J, Darby G, Jones Y, Stuart D, et al., Nat Struct Biol. 1995 Apr;2(4):293-302. PMID:7540934 Page seeded by OCA on Sat May 3 07:53:17 2008

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