User:Birger Lenz/Sandbox 4x09
From Proteopedia
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The complete RNase is 1.72 Å tall and is composed of 128 amino acids (17kDa). It is organized in <scene name='75/750256/4x09_helix_focus/3'>3 helices</scene> and <scene name='75/750256/4x09_sheet_focus/1'>7 sheets</scene>. The structure forms an overall kidney-shaped globe which characterizes the RNases A. 4 disulfide bonds are responsible for this structure. There is another possible conformation for the N-terminal domain in which the Trp folds back towards the protein core. | The complete RNase is 1.72 Å tall and is composed of 128 amino acids (17kDa). It is organized in <scene name='75/750256/4x09_helix_focus/3'>3 helices</scene> and <scene name='75/750256/4x09_sheet_focus/1'>7 sheets</scene>. The structure forms an overall kidney-shaped globe which characterizes the RNases A. 4 disulfide bonds are responsible for this structure. There is another possible conformation for the N-terminal domain in which the Trp folds back towards the protein core. | ||
The crystal structure shows a secondary active site which allows to catalyze the hydrolysis of the target RNA. | The crystal structure shows a secondary active site which allows to catalyze the hydrolysis of the target RNA. | ||
| - | The protein was crystallized in presence of ammonium sulfate and 4 sulfate anions were identified (interactions with residues His37, His40, Arg67 and His68 which are cationic residues, exposed at the protein surface, and interactions with the residues His16, His123 and Gln15 in the main active site, conserved in all RNase A) | + | The protein was crystallized in presence of ammonium sulfate and <scene name='75/750256/4x09_sulfate_focus/1'>4 sulfate anions</scene> were identified (interactions with residues His37, His40, Arg67 and His68 which are cationic residues, exposed at the protein surface, and interactions with the residues His16, His123 and Gln15 in the main active site, conserved in all RNase A). |
== Disease == | == Disease == | ||
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| - | == Relevance == | ||
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| - | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 16:54, 24 January 2017
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