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1rvf
From Proteopedia
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'''FAB COMPLEXED WITH INTACT HUMAN RHINOVIRUS''' | '''FAB COMPLEXED WITH INTACT HUMAN RHINOVIRUS''' | ||
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[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Smith, T J.]] | [[Category: Smith, T J.]] | ||
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| - | [[Category: | + | [[Category: Hydrolase]] |
| - | [[Category: | + | [[Category: Icosahedral virus]] |
| - | + | [[Category: Myristylation]] | |
| - | [[Category: | + | [[Category: Polyprotein]] |
| - | [[Category: | + | [[Category: Rna-directed rna polymerase]] |
| - | [[Category: | + | [[Category: Thiol protease]] |
| - | [[Category: | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:57:27 2008'' |
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Revision as of 04:57, 3 May 2008
FAB COMPLEXED WITH INTACT HUMAN RHINOVIRUS
Overview
The three-dimensional structure of intact human rhinovirus 14 (HRV-14) complexed with Fab fragments (Fab17-IA) from a strongly neutralizing antibody that binds bivalently to the virion has been determined to 4.0 angstrom resolution by a combination of X-ray crystallography and cryo-electron microscopy. In contradiction to the most commonly held model of antibody-mediated neutralization, Fab17-IA does not induce a conformational change in the HRV-14 capsid. Instead, the paratope of the antibody undergoes a large conformational change to accommodate the epitope. Unlike any previously described antibody-antigen structure, the conserved framework region of the antibody makes extensive contact with the viral surface. Fab17-IA penetrates deep within the canyon in which the cellular receptor for HRV-14 binds. Hence, it is unlikely that viral quaternary structure evolves merely to evade immune recognition. Instead, the shape and position of the receptor-binding region on a virus probably dictates receptor binding and subsequent uncoating events and has little or no influence on concealing the virus from the immune system.
About this Structure
1RVF is a Protein complex structure of sequences from Human rhinovirus 14, Human rhinovirus sp. and Mus musculus. The following page contains interesting information on the relation of 1RVF with [Poliovirus and Rhinovirus]. Full crystallographic information is available from OCA.
Reference
Neutralizing antibody to human rhinovirus 14 penetrates the receptor-binding canyon., Smith TJ, Chase ES, Schmidt TJ, Olson NH, Baker TS, Nature. 1996 Sep 26;383(6598):350-4. PMID:8848050 Page seeded by OCA on Sat May 3 07:57:27 2008
