1rvt
From Proteopedia
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[[Image:1rvt.gif|left|200px]] | [[Image:1rvt.gif|left|200px]] | ||
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'''1930 H1 Hemagglutinin in complex with LSTC''' | '''1930 H1 Hemagglutinin in complex with LSTC''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | + | Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RVT OCA]. | |
==Reference== | ==Reference== | ||
The structure and receptor binding properties of the 1918 influenza hemagglutinin., Gamblin SJ, Haire LF, Russell RJ, Stevens DJ, Xiao B, Ha Y, Vasisht N, Steinhauer DA, Daniels RS, Elliot A, Wiley DC, Skehel JJ, Science. 2004 Mar 19;303(5665):1838-42. Epub 2004 Feb 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14764886 14764886] | The structure and receptor binding properties of the 1918 influenza hemagglutinin., Gamblin SJ, Haire LF, Russell RJ, Stevens DJ, Xiao B, Ha Y, Vasisht N, Steinhauer DA, Daniels RS, Elliot A, Wiley DC, Skehel JJ, Science. 2004 Mar 19;303(5665):1838-42. Epub 2004 Feb 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14764886 14764886] | ||
| - | [[Category: Protein complex]] | ||
| - | [[Category: Unidentified influenza virus]] | ||
[[Category: Daniels, R S.]] | [[Category: Daniels, R S.]] | ||
[[Category: Gamblin, S J.]] | [[Category: Gamblin, S J.]] | ||
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[[Category: Vasisht, N.]] | [[Category: Vasisht, N.]] | ||
[[Category: Xiao, B.]] | [[Category: Xiao, B.]] | ||
| - | [[Category: | + | [[Category: Hemagglutinin]] |
| - | [[Category: | + | [[Category: Influenza a virus]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:57:45 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 04:57, 3 May 2008
1930 H1 Hemagglutinin in complex with LSTC
Overview
The 1918 influenza pandemic resulted in about 20 million deaths. This enormous impact, coupled with renewed interest in emerging infections, makes characterization of the virus involved a priority. Receptor binding, the initial event in virus infection, is a major determinant of virus transmissibility that, for influenza viruses, is mediated by the hemagglutinin (HA) membrane glycoprotein. We have determined the crystal structures of the HA from the 1918 virus and two closely related HAs in complex with receptor analogs. They explain how the 1918 HA, while retaining receptor binding site amino acids characteristic of an avian precursor HA, is able to bind human receptors and how, as a consequence, the virus was able to spread in the human population.
About this Structure
Full crystallographic information is available from OCA.
Reference
The structure and receptor binding properties of the 1918 influenza hemagglutinin., Gamblin SJ, Haire LF, Russell RJ, Stevens DJ, Xiao B, Ha Y, Vasisht N, Steinhauer DA, Daniels RS, Elliot A, Wiley DC, Skehel JJ, Science. 2004 Mar 19;303(5665):1838-42. Epub 2004 Feb 5. PMID:14764886 Page seeded by OCA on Sat May 3 07:57:45 2008
