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1rw7

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[[Image:1rw7.jpg|left|200px]]
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{{Structure
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|GENE= YDR533C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rw7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rw7 OCA], [http://www.ebi.ac.uk/pdbsum/1rw7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1rw7 RCSB]</span>
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'''Crystal Structure of YDR533Cp'''
'''Crystal Structure of YDR533Cp'''
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[[Category: St Amour, C V.]]
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[[Category: Wilson, M A.]]
[[Category: Wilson, M A.]]
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[[Category: alpha-beta sandwich]]
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[[Category: Alpha-beta sandwich]]
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[[Category: dj-1/thij/pfpi superfamily]]
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[[Category: Dj-1/thij/pfpi superfamily]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:58:48 2008''
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Revision as of 04:58, 3 May 2008

Image:1rw7.jpg

Template:STRUCTURE 1rw7

Crystal Structure of YDR533Cp


Overview

The yeast gene YDR533C encodes a protein belonging to the DJ-1/ThiJ/PfpI superfamily. This family includes the human protein DJ-1, which is mutated in autosomal recessive early-onset Parkinson's disease. The function of DJ-1 and its yeast homologue YDR533Cp is unknown. We report here the crystal structure of YDR533Cp at 1.8-A resolution. The structure indicates that the closest relative to YDR533Cp is the Escherichia coli heat shock protein Hsp31 (YedU), which has both chaperone and protease activity. As expected, the overall fold of the core domain of YDR533Cp is also similar to that of DJ-1 and the bacterial protease PfpI. YDR533Cp contains a possible catalytic triad analogous to that of Hsp31 and an additional domain that is present in Hsp31 but is not seen in DJ-1 and other members of the family. The cysteine in this triad (Cys-138) is oxidized in this crystal structure, similar to modifications seen in the corresponding cysteine in the crystal structure of DJ-1. YDR533Cp appears to be a dimer both in solution and the crystal, but this dimer is formed by a different interface than that found in Hsp31 or other members of the superfamily.

About this Structure

1RW7 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

The 1.8-A resolution crystal structure of YDR533Cp from Saccharomyces cerevisiae: a member of the DJ-1/ThiJ/PfpI superfamily., Wilson MA, St Amour CV, Collins JL, Ringe D, Petsko GA, Proc Natl Acad Sci U S A. 2004 Feb 10;101(6):1531-6. Epub 2004 Jan 26. PMID:14745011 Page seeded by OCA on Sat May 3 07:58:48 2008

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