1rxl

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[[Image:1rxl.gif|left|200px]]
[[Image:1rxl.gif|left|200px]]
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{{Structure
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|PDB= 1rxl |SIZE=350|CAPTION= <scene name='initialview01'>1rxl</scene>
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The line below this paragraph, containing "STRUCTURE_1rxl", creates the "Structure Box" on the page.
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|SITE=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|GENE= afae3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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|DOMAIN=
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{{STRUCTURE_1rxl| PDB=1rxl | SCENE= }}
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|RELATEDENTRY=[[1sdd|1SDD]], [[1ut2|1UT2]], [[1ut1|1UT1]], [[1usq|1USQ]], [[1usz|1USZ]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rxl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rxl OCA], [http://www.ebi.ac.uk/pdbsum/1rxl PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1rxl RCSB]</span>
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}}
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'''Solution structure of the engineered protein Afae-dsc'''
'''Solution structure of the engineered protein Afae-dsc'''
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[[Category: Smith, R A.]]
[[Category: Smith, R A.]]
[[Category: Urvil, P.]]
[[Category: Urvil, P.]]
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[[Category: afae]]
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[[Category: Afae]]
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[[Category: afimbrial sheath]]
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[[Category: Afimbrial sheath]]
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[[Category: daec]]
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[[Category: Daec]]
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[[Category: daf]]
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[[Category: Daf]]
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[[Category: donor strand complemented]]
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[[Category: Donor strand complemented]]
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[[Category: ig-like domain]]
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[[Category: Ig-like domain]]
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[[Category: nmr]]
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[[Category: Nmr]]
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[[Category: upec]]
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[[Category: Upec]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:01:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:34:22 2008''
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Revision as of 05:01, 3 May 2008

Image:1rxl.gif

Template:STRUCTURE 1rxl

Solution structure of the engineered protein Afae-dsc


Overview

Pathogenic bacteria possess adhesion protein complexes that play essential roles in targeting host cells and in propagating infection. Although each family of adhesion proteins is generally associated with a specific human disease, the Dr family from Escherichia coli is a notable exception, as its members are associated with both diarrheal and urinary tract infections. These proteins are reported to form both fimbrial and afimbrial structures at the bacterial cell surface and target a common host cell receptor, the decay-accelerating factor (DAF or CD55). Using the newly solved three-dimensional structure of AfaE, we have constructed a robust atomic resolution model that reveals the structural basis for assembly by donor strand complementation and for the architecture of capped surface fibers.

About this Structure

1RXL is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

An atomic resolution model for assembly, architecture, and function of the Dr adhesins., Anderson KL, Billington J, Pettigrew D, Cota E, Simpson P, Roversi P, Chen HA, Urvil P, du Merle L, Barlow PN, Medof ME, Smith RA, Nowicki B, Le Bouguenec C, Lea SM, Matthews S, Mol Cell. 2004 Aug 27;15(4):647-57. PMID:15327779 Page seeded by OCA on Sat May 3 08:01:47 2008

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