1ry1

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[[Image:1ry1.gif|left|200px]]
[[Image:1ry1.gif|left|200px]]
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{{Structure
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|PDB= 1ry1 |SIZE=350|CAPTION= <scene name='initialview01'>1ry1</scene>, resolution 12.&Aring;
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The line below this paragraph, containing "STRUCTURE_1ry1", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=CCC:CYTIDINE-5&#39;-PHOSPHATE-2&#39;,3&#39;-CYCLIC+PHOSPHATE'>CCC</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=GDP:GUANOSINE-5&#39;-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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|GENE= SRP14 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), SRP19 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), FFH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=271 Thermus aquaticus]), SRP54 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), RHO ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9739 Tursiops truncatus]), SRP9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_1ry1| PDB=1ry1 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ry1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ry1 OCA], [http://www.ebi.ac.uk/pdbsum/1ry1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ry1 RCSB]</span>
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'''Structure of the signal recognition particle interacting with the elongation-arrested ribosome'''
'''Structure of the signal recognition particle interacting with the elongation-arrested ribosome'''
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[[Category: Pool, M R.]]
[[Category: Pool, M R.]]
[[Category: Spahn, C M.]]
[[Category: Spahn, C M.]]
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[[Category: rna binding]]
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[[Category: Rna binding]]
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[[Category: signal recognition particle]]
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[[Category: Signal recognition particle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:02:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:34:36 2008''
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Revision as of 05:02, 3 May 2008

Image:1ry1.gif

Template:STRUCTURE 1ry1

Structure of the signal recognition particle interacting with the elongation-arrested ribosome


Overview

Cotranslational translocation of proteins across or into membranes is a vital process in all kingdoms of life. It requires that the translating ribosome be targeted to the membrane by the signal recognition particle (SRP), an evolutionarily conserved ribonucleoprotein particle. SRP recognizes signal sequences of nascent protein chains emerging from the ribosome. Subsequent binding of SRP leads to a pause in peptide elongation and to the ribosome docking to the membrane-bound SRP receptor. Here we present the structure of a targeting complex consisting of mammalian SRP bound to an active 80S ribosome carrying a signal sequence. This structure, solved to 12 A by cryo-electron microscopy, enables us to generate a molecular model of SRP in its functional conformation. The model shows how the S domain of SRP contacts the large ribosomal subunit at the nascent chain exit site to bind the signal sequence, and that the Alu domain reaches into the elongation-factor-binding site of the ribosome, explaining its elongation arrest activity.

About this Structure

1RY1 is a Protein complex structure of sequences from Homo sapiens, Mus musculus, Thermus aquaticus and Tursiops truncatus. Full crystallographic information is available from OCA.

Reference

Structure of the signal recognition particle interacting with the elongation-arrested ribosome., Halic M, Becker T, Pool MR, Spahn CM, Grassucci RA, Frank J, Beckmann R, Nature. 2004 Feb 26;427(6977):808-14. PMID:14985753 Page seeded by OCA on Sat May 3 08:02:50 2008

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