1ryh

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[[Image:1ryh.gif|left|200px]]
[[Image:1ryh.gif|left|200px]]
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{{Structure
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|PDB= 1ryh |SIZE=350|CAPTION= <scene name='initialview01'>1ryh</scene>, resolution 1.75&Aring;
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The line below this paragraph, containing "STRUCTURE_1ryh", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Small_monomeric_GTPase Small monomeric GTPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.5.2 3.6.5.2] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1ryh| PDB=1ryh | SCENE= }}
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|RELATEDENTRY=[[1ryf|1RYF]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ryh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ryh OCA], [http://www.ebi.ac.uk/pdbsum/1ryh PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ryh RCSB]</span>
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}}
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'''Alternative Splicing of Rac1 Generates Rac1b, a Self-activating GTPase'''
'''Alternative Splicing of Rac1 Generates Rac1b, a Self-activating GTPase'''
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[[Category: Ahmadian, M R.]]
[[Category: Ahmadian, M R.]]
[[Category: Fiegen, D.]]
[[Category: Fiegen, D.]]
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[[Category: gtp binding]]
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[[Category: Gtp binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:03:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:34:45 2008''
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Revision as of 05:03, 3 May 2008

Image:1ryh.gif

Template:STRUCTURE 1ryh

Alternative Splicing of Rac1 Generates Rac1b, a Self-activating GTPase


Overview

Rac1b was recently identified in malignant colorectal tumors as an alternative splice variant of Rac1 containing a 19-amino acid insertion next to the switch II region. The structures of Rac1b in the GDP- and the GppNHp-bound forms, determined at a resolution of 1.75 A, reveal that the insertion induces an open switch I conformation and a highly mobile switch II. As a consequence, Rac1b has an accelerated GEF-independent GDP/GTP exchange and an impaired GTP hydrolysis, which is restored partially by GTPase-activating proteins. Interestingly, Rac1b is able to bind the GTPase-binding domain of PAK but not full-length PAK in a GTP-dependent manner, suggesting that the insertion does not completely abolish effector interaction. The presented study provides insights into the structural and biochemical mechanism of a self-activating GTPase.

About this Structure

1RYH is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Alternative splicing of Rac1 generates Rac1b, a self-activating GTPase., Fiegen D, Haeusler LC, Blumenstein L, Herbrand U, Dvorsky R, Vetter IR, Ahmadian MR, J Biol Chem. 2004 Feb 6;279(6):4743-9. Epub 2003 Nov 18. PMID:14625275 Page seeded by OCA on Sat May 3 08:03:52 2008

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