This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4wsy
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Crystal structure of human Pim-1 kinase in complex with a thiazolamine-indazole inhibitor.== | ==Crystal structure of human Pim-1 kinase in complex with a thiazolamine-indazole inhibitor.== | ||
| - | <StructureSection load='4wsy' size='340' side='right' caption='[[4wsy]], [[Resolution|resolution]] 2.30Å' scene=''> | + | <StructureSection load='4wsy' size='340' side='right'caption='[[4wsy]], [[Resolution|resolution]] 2.30Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4wsy]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WSY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WSY FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4wsy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WSY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WSY FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3U5:5-[3-(QUINOLIN-3-YL)-2H-INDAZOL-5-YL]-1,3-THIAZOL-2-AMINE'>3U5</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3U5:5-[3-(QUINOLIN-3-YL)-2H-INDAZOL-5-YL]-1,3-THIAZOL-2-AMINE'>3U5</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4wt6|4wt6]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4wt6|4wt6]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PIM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wsy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wsy OCA], [http://pdbe.org/4wsy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wsy RCSB], [http://www.ebi.ac.uk/pdbsum/4wsy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wsy ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wsy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wsy OCA], [http://pdbe.org/4wsy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wsy RCSB], [http://www.ebi.ac.uk/pdbsum/4wsy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wsy ProSAT]</span></td></tr> | ||
| Line 20: | Line 21: | ||
</div> | </div> | ||
<div class="pdbe-citations 4wsy" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 4wsy" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Proto-oncogene serine/threonine-protein kinase|Proto-oncogene serine/threonine-protein kinase]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Non-specific serine/threonine protein kinase]] | [[Category: Non-specific serine/threonine protein kinase]] | ||
[[Category: Mohr, C]] | [[Category: Mohr, C]] | ||
Revision as of 08:10, 23 May 2019
Crystal structure of human Pim-1 kinase in complex with a thiazolamine-indazole inhibitor.
| |||||||||||
