4wh8
From Proteopedia
(Difference between revisions)
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==Crystal Structure of HCV NS3/4A protease in complex with an Asunaprevir P1-P3 macrocyclic analog.== | ==Crystal Structure of HCV NS3/4A protease in complex with an Asunaprevir P1-P3 macrocyclic analog.== | ||
| - | <StructureSection load='4wh8' size='340' side='right' caption='[[4wh8]], [[Resolution|resolution]] 2.70Å' scene=''> | + | <StructureSection load='4wh8' size='340' side='right'caption='[[4wh8]], [[Resolution|resolution]] 2.70Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4wh8]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WH8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WH8 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4wh8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus_subtype_1a Hepatitis c virus subtype 1a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WH8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WH8 FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3M7:TERT-BUTYL+[(2R,6S,12Z,13AS,14AR,16AS)-2-[(7-CHLORO-4-METHOXYISOQUINOLIN-1-YL)OXY]-14A-{[CYCLOPROPYL(DIHYDROXY)-LAMBDA~4~-SULFANYL]CARBAMOYL}-5,16-DIOXO-1,2,3,5,6,7,8,9,10,11,13A,14,14A,15,16,16A-HEXADECAHYDROCYCLOPROPA[E]PYRROLO[1,2-A][1,4]DIAZACYCLOPENTADECIN-6-YL]CARBAMATE'>3M7</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3M7:TERT-BUTYL+[(2R,6S,12Z,13AS,14AR,16AS)-2-[(7-CHLORO-4-METHOXYISOQUINOLIN-1-YL)OXY]-14A-{[CYCLOPROPYL(DIHYDROXY)-LAMBDA~4~-SULFANYL]CARBAMOYL}-5,16-DIOXO-1,2,3,5,6,7,8,9,10,11,13A,14,14A,15,16,16A-HEXADECAHYDROCYCLOPROPA[E]PYRROLO[1,2-A][1,4]DIAZACYCLOPENTADECIN-6-YL]CARBAMATE'>3M7</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4wh6|4wh6]], [[4wf8|4wf8]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4wh6|4wh6]], [[4wf8|4wf8]]</td></tr> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Hepatitis c virus subtype 1a]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Ali, A]] | [[Category: Ali, A]] | ||
[[Category: Schiffer, C A]] | [[Category: Schiffer, C A]] | ||
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[[Category: Asunaprevir]] | [[Category: Asunaprevir]] | ||
[[Category: Hcv drug resistance]] | [[Category: Hcv drug resistance]] | ||
| + | [[Category: Hydrolase-hydrolase inhibitor complex]] | ||
[[Category: Macrocycle]] | [[Category: Macrocycle]] | ||
[[Category: Protease-inhibitor complex]] | [[Category: Protease-inhibitor complex]] | ||
Revision as of 09:03, 23 May 2019
Crystal Structure of HCV NS3/4A protease in complex with an Asunaprevir P1-P3 macrocyclic analog.
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