1s1g

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{{Structure
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The line below this paragraph, containing "STRUCTURE_1s1g", creates the "Structure Box" on the page.
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|GENE= KCND3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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{{STRUCTURE_1s1g| PDB=1s1g | SCENE= }}
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|RELATEDENTRY=[[1s1e|1S1E]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s1g OCA], [http://www.ebi.ac.uk/pdbsum/1s1g PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1s1g RCSB]</span>
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'''Crystal Structure of Kv4.3 T1 Domain'''
'''Crystal Structure of Kv4.3 T1 Domain'''
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[[Category: Xu, W X.]]
[[Category: Xu, W X.]]
[[Category: Xu, Z B.]]
[[Category: Xu, Z B.]]
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[[Category: k+ channel]]
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[[Category: K+ channel]]
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[[Category: t1 domain]]
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[[Category: T1 domain]]
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[[Category: tetramerization domain]]
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[[Category: Tetramerization domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:10:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:35:59 2008''
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Revision as of 05:10, 3 May 2008

Image:1s1g.jpg

Template:STRUCTURE 1s1g

Crystal Structure of Kv4.3 T1 Domain


Overview

The family of calcium binding proteins called KChIPs associates with Kv4 family K(+) channels and modulates their biophysical properties. Here, using mutagenesis and X-ray crystallography, we explore the interaction between Kv4 subunits and KChIP1. Two regions in the Kv4.2 N terminus, residues 7-11 and 71-90, are necessary for KChIP1 modulation and interaction with Kv4.2. When inserted into the Kv1.2 N terminus, residues 71-90 of Kv4.2 are also sufficient to confer association with KChIP1. To provide a structural framework for these data, we solved the crystal structures of Kv4.3N and KChIP1 individually. Taken together with the mutagenesis data, the individual structures suggest that that the Kv4 N terminus is required for stable association with KChIP1, perhaps through a hydrophobic surface interaction, and that residues 71-90 in Kv4 subunits form a contact loop that mediates the specific association of KChIPs with Kv4 subunits.

About this Structure

1S1G is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1., Scannevin RH, Wang K, Jow F, Megules J, Kopsco DC, Edris W, Carroll KC, Lu Q, Xu W, Xu Z, Katz AH, Olland S, Lin L, Taylor M, Stahl M, Malakian K, Somers W, Mosyak L, Bowlby MR, Chanda P, Rhodes KJ, Neuron. 2004 Feb 19;41(4):587-98. PMID:14980207 Page seeded by OCA on Sat May 3 08:10:31 2008

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