1s1j

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1s1j.jpg|left|200px]]
[[Image:1s1j.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1s1j |SIZE=350|CAPTION= <scene name='initialview01'>1s1j</scene>, resolution 2.18&Aring;
+
The line below this paragraph, containing "STRUCTURE_1s1j", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=IQZ:(7AS,12AR,12BS)-1,2,3,4,7A,12,12A,12B-OCTAHYDROINDOLO[2,3-A]QUINOLIZIN-7(6H)-ONE'>IQZ</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE= ZIPA, B2412 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1s1j| PDB=1s1j | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s1j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s1j OCA], [http://www.ebi.ac.uk/pdbsum/1s1j PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1s1j RCSB]</span>
+
-
}}
+
'''Crystal Structure of ZipA in complex with indoloquinolizin inhibitor 1'''
'''Crystal Structure of ZipA in complex with indoloquinolizin inhibitor 1'''
Line 40: Line 37:
[[Category: Tsao, D H.]]
[[Category: Tsao, D H.]]
[[Category: Tuckman, M.]]
[[Category: Tuckman, M.]]
-
[[Category: cell cycle]]
+
[[Category: Cell cycle]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:10:44 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:36:02 2008''
+

Revision as of 05:10, 3 May 2008

Image:1s1j.jpg

Template:STRUCTURE 1s1j

Crystal Structure of ZipA in complex with indoloquinolizin inhibitor 1


Overview

The binding of FtsZ to ZipA is a potential target for antibacterial therapy. Based on a small molecule inhibitor of the ZipA-FtsZ interaction, a parallel synthesis of small molecules was initiated which targeted a key region of ZipA involved in FtsZ binding. The X-ray crystal structure of one of these molecules complexed with ZipA was solved. The structure revealed an unexpected binding mode, facilitated by desolvation of a loosely bound surface water.

About this Structure

1S1J is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Design and synthesis of indolo[2,3-a]quinolizin-7-one inhibitors of the ZipA-FtsZ interaction., Jennings LD, Foreman KW, Rush TS 3rd, Tsao DH, Mosyak L, Li Y, Sukhdeo MN, Ding W, Dushin EG, Kenny CH, Moghazeh SL, Petersen PJ, Ruzin AV, Tuckman M, Sutherland AG, Bioorg Med Chem Lett. 2004 Mar 22;14(6):1427-31. PMID:15006376 Page seeded by OCA on Sat May 3 08:10:44 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1s1j"
Personal tools