1s1q

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1s1q.gif|left|200px]]
[[Image:1s1q.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1s1q |SIZE=350|CAPTION= <scene name='initialview01'>1s1q</scene>, resolution 2.00&Aring;
+
The line below this paragraph, containing "STRUCTURE_1s1q", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1s1q| PDB=1s1q | SCENE= }}
-
|RELATEDENTRY=[[1kpp|1KPP]], [[1kpq|1KPQ]], [[1m4p|1M4P]], [[1m4q|1M4Q]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s1q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s1q OCA], [http://www.ebi.ac.uk/pdbsum/1s1q PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1s1q RCSB]</span>
+
-
}}
+
'''TSG101(UEV) domain in complex with Ubiquitin'''
'''TSG101(UEV) domain in complex with Ubiquitin'''
Line 31: Line 28:
[[Category: Schubert, H L.]]
[[Category: Schubert, H L.]]
[[Category: Sundquist, W I.]]
[[Category: Sundquist, W I.]]
-
[[Category: heterodimer]]
+
[[Category: Heterodimer]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:11:23 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:36:07 2008''
+

Revision as of 05:11, 3 May 2008

Image:1s1q.gif

Template:STRUCTURE 1s1q

TSG101(UEV) domain in complex with Ubiquitin


Overview

The UEV domain of the TSG101 protein functions in both HIV-1 budding and the vacuolar protein sorting (VPS) pathway, where it binds ubiquitylated proteins as they are sorted into vesicles that bud into late endosomal compartments called multivesicular bodies (MVBs). TSG101 UEV-ubiquitin interactions are therefore important for delivery of both substrates and hydrolytic enzymes to lysosomes, which receive proteins via fusion with MVBs. Here, we report the crystal structure of the TSG101 UEV domain in complex with ubiquitin at 2.0 A resolution. TSG101 UEV contacts the Ile44 surface and an adjacent loop of ubiquitin through a highly solvated interface. Mutations that disrupt the interface inhibit MVB sorting, and the structure also explains how the TSG101 UEV can independently bind its ubiquitin and Pro-Thr/Ser-Ala-Pro peptide ligands. Remarkably, comparison with mapping data from other UEV and related E2 proteins indicates that although the different E2/UEV domains share the same structure and have conserved ubiquitin binding activity, they bind through very different interfaces.

About this Structure

1S1Q is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Ubiquitin recognition by the human TSG101 protein., Sundquist WI, Schubert HL, Kelly BN, Hill GC, Holton JM, Hill CP, Mol Cell. 2004 Mar 26;13(6):783-9. PMID:15053872 Page seeded by OCA on Sat May 3 08:11:23 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1s1q"
Personal tools