IGF1
From Proteopedia
(Difference between revisions)
(New page: = Insulin-like growth factor 1 = <StructureSection load='1gzr' size='340' side='right' caption='Structural basis for IGF1 protein with N-DODECYL-N,N-DIMETHYL-3-AMMONIO-1-PROPANESULFONATE ...) |
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<StructureSection load='1gzr' size='340' side='right' caption='Structural basis for IGF1 protein with N-DODECYL-N,N-DIMETHYL-3-AMMONIO-1-PROPANESULFONATE ligand' scene=''> | <StructureSection load='1gzr' size='340' side='right' caption='Structural basis for IGF1 protein with N-DODECYL-N,N-DIMETHYL-3-AMMONIO-1-PROPANESULFONATE ligand' scene=''> | ||
| - | + | Insulin is a very important endocrine protein. Indeed, it is the only hypoglycemic hormone of the human body. This protein is secreted in the beta cells of the Langerhans’ islet in the pancreas and takes part in the glycogenesis. This molecule helps the transportation of glucose into the cells, thus reducing the blood sugar rate, contrary to glucagon. | |
| + | Insulin also has a huge effect on growth and thereby has a lot of structural similarities with its main associated growth factor: IGF-1. Both share lots of properties thanks to their 60% similarity. | ||
| + | IGF-1 is a peptidic hormone of 69 amino acids which is secreted by the liver. | ||
| + | This protein deals with a large scale of regulations, from growth to nutrition and it is even implied in stress response, breeding and longevity.(pdf 2013NICE4102). | ||
| + | It is the main actor in primary growth cell control. | ||
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== History == | == History == | ||
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== Biological structures and interactions == | == Biological structures and interactions == | ||
=== Structures === | === Structures === | ||
| + | IGF-1 is a 8.28 kDa protein consisting of 69 amino acids. | ||
| + | The coding RNA of this protein creates 4 isoforms differing from each other due to RNA splicing. | ||
| + | Nevertheless, all 4 of them have cysteine residues that are able to make disulfide bond. This enable them to link to IGF-1 receptor. | ||
| + | It’s secondary structure as shown here is composed of alpha helix and beta strand. | ||
=== Stimulating interaction : IGF1 - IGF1R === | === Stimulating interaction : IGF1 - IGF1R === | ||
Revision as of 14:52, 26 January 2017
Insulin-like growth factor 1
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References
Proteopedia Page Contributors and Editors (what is this?)
Maxime Julliot, Alexia Kindler, Virginie Nakad, Michal Harel, Alexander Berchansky
