1s3a
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:1s3a.gif|left|200px]] | [[Image:1s3a.gif|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_1s3a", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | + | or leave the SCENE parameter empty for the default display. | |
| - | + | --> | |
| - | + | {{STRUCTURE_1s3a| PDB=1s3a | SCENE= }} | |
| - | + | ||
| - | | | + | |
| - | }} | + | |
'''NMR Solution Structure of Subunit B8 from Human NADH-Ubiquinone Oxidoreductase Complex I (CI-B8)''' | '''NMR Solution Structure of Subunit B8 from Human NADH-Ubiquinone Oxidoreductase Complex I (CI-B8)''' | ||
| Line 30: | Line 27: | ||
[[Category: Oschkinat, H.]] | [[Category: Oschkinat, H.]] | ||
[[Category: Rehbein, K.]] | [[Category: Rehbein, K.]] | ||
| - | [[Category: | + | [[Category: Ci-b8]] |
| - | [[Category: | + | [[Category: Complex i]] |
| - | [[Category: | + | [[Category: Ndufa2]] |
| - | [[Category: | + | [[Category: Nmr]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:14:34 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 05:14, 3 May 2008
NMR Solution Structure of Subunit B8 from Human NADH-Ubiquinone Oxidoreductase Complex I (CI-B8)
Overview
Subunit B8 from ubiquinone oxidoreductase (complex I) (CI-B8) is one of several nuclear-encoded supernumerary subunits that are not present in bacterial complex I. Its solution structure shows a thioredoxin fold with highest similarities to the human thioredoxin mutant C73S and thioredoxin 2 from Anabeana sp. Interestingly, these proteins contain active sites in the same area, where the disulfide bond of oxidized CI-B8 is located. The redox potential of this disulfide bond is -251.6 mV, comparing well to that of disulfides in other thioredoxin-like proteins. Analysis of the structure reveals a surface area that is exclusively composed of highly conserved residues and thus most likely a subunit interaction site within complex I.
About this Structure
1S3A is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The oxidized subunit B8 from human complex I adopts a thioredoxin fold., Brockmann C, Diehl A, Rehbein K, Strauss H, Schmieder P, Korn B, Kuhne R, Oschkinat H, Structure. 2004 Sep;12(9):1645-54. PMID:15341729 Page seeded by OCA on Sat May 3 08:14:34 2008
Categories: Homo sapiens | Single protein | Brockmann, C. | Diehl, A. | Kuhne, R. | Oschkinat, H. | Rehbein, K. | Ci-b8 | Complex i | Ndufa2 | Nmr
