Ubiquitin protein ligase
From Proteopedia
(Difference between revisions)
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== Disease == | == Disease == | ||
| - | XIAP mutations cause X-linked lymphoproliferative syndrome type 2<ref>PMID:24942515</ref>. Parkin UPL has a direct causal role in neurodegenerative disorders<ref>PMID:16908979</ref>. | + | XIAP mutations cause X-linked lymphoproliferative syndrome type 2<ref>PMID:24942515</ref>. Parkin UPL has a direct causal role in neurodegenerative disorders<ref>PMID:16908979</ref>. Cereblon nonsense mutation causes autosomal recessive nonsyndromic mental retardation<ref>PMID:23983124</ref>. |
== Relevance == | == Relevance == | ||
| - | Overexpression of UPL XIAP functions as tumor marker. UPL '''cereblon''' is inhibited by thalidomide<ref>PMID:24292623</ref>. | + | Overexpression of UPL XIAP functions as tumor marker. UPL '''cereblon''' is inhibited by thalidomide<ref>PMID:24292623</ref>. |
== Structural highlights == | == Structural highlights == | ||
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* '''TKB''' – Tyrosine Kinase Binding domain;<br /> | * '''TKB''' – Tyrosine Kinase Binding domain;<br /> | ||
* '''C2''' – an 8 β strand domain which coordinates targeting proteins toward cell membrane;<br /> | * '''C2''' – an 8 β strand domain which coordinates targeting proteins toward cell membrane;<br /> | ||
| + | * '''Cereblon''' is a target for thalidomide;<br /> | ||
* '''HECT''' – Homologous to the E6-AP C-terminus;<br /> | * '''HECT''' – Homologous to the E6-AP C-terminus;<br /> | ||
* '''RING''' – Really Intersting New Gene involved in binding to E2;<br /> | * '''RING''' – Really Intersting New Gene involved in binding to E2;<br /> | ||
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**[[5trb]] – hUPL RNF20 domain<br /> | **[[5trb]] – hUPL RNF20 domain<br /> | ||
**[[4r7e]] – hUPL RING domain<br /> | **[[4r7e]] – hUPL RING domain<br /> | ||
| + | |||
| + | *UPL cereblon | ||
| + | |||
| + | **[[5ami]] – MgCRBN 4 – ''Magnetospirillum griphyswaldense''<br /> | ||
| + | **[[5amh]], [[5maj]], [[5amk]], [[4v2r]] – MgCer 4 + thalidomide<br /> | ||
| + | **[[4v32]] – MgCRBN 4 (mutant) + thalidomide<br /> | ||
| + | **[[4v2z]] – MgCRBN 4 + pomalidomide<br /> | ||
| + | **[[4v30]] – MgCRBN 4 + lenalidomide<br /> | ||
| + | **[[4v31]] – MgCRBN 4 + deoxyuridine<br /> | ||
| + | **[[5hxb]] – hCeRBN+ DNA damage-binding protein + eukaryotic peptide chain release factor<br /> | ||
| + | **[[5fqd]] – hCRBN + DNA damage-binding protein + casein kinase I + lenalidomide<br /> | ||
| + | **[[4tz4]] – hCRBN + DNA damage-binding protein + lenalidomide<br /> | ||
| + | **[[3wx1]], [[3wx2]] – mCRBN thalidomide-binding domain<br /> | ||
| + | **[[4tzc]] – mCRBN + thalidomide<br /> | ||
| + | **[[4tzu]] – mCRBN + pomalidomide<br /> | ||
| + | **[[4ci1]] – cCRBN + DNA damage-binding protein + thalidomide - chicken<br /> | ||
| + | **[[4ci2]] – cCRBN + DNA damage-binding protein + lenalidomide<br /> | ||
| + | **[[4ci3]] – cCRBN + DNA damage-binding protein + pomalidomide<br /> | ||
*'''Ubiquitin protein ligase CHFR''' | *'''Ubiquitin protein ligase CHFR''' | ||
Revision as of 08:48, 31 January 2017
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3D Structures of ubiquitin protein ligase
Updated on 31-January-2017
References
- ↑ Ardley HC, Robinson PA. E3 ubiquitin ligases. Essays Biochem. 2005;41:15-30. PMID:16250895 doi:http://dx.doi.org/10.1042/EB0410015
- ↑ Sakemi R, Yano H, Ogasawara S, Akiba J, Nakashima O, Fukahori S, Sata M, Kojiro M. X-linked inhibitor of apoptosis (XIAP) and XIAP-associated factor-1 expressions and their relationship to apoptosis in human hepatocellular carcinoma and non-cancerous liver tissues. Oncol Rep. 2007 Jul;18(1):65-70. PMID:17549347
- ↑ Aguilar C, Lenoir C, Lambert N, Begue B, Brousse N, Canioni D, Berrebi D, Roy M, Gerart S, Chapel H, Schwerd T, Siproudhis L, Schappi M, Al-Ahmari A, Mori M, Yamaide A, Galicier L, Neven B, Routes J, Uhlig HH, Koletzko S, Patel S, Kanegane H, Picard C, Fischer A, Bensussan NC, Ruemmele F, Hugot JP, Latour S. Characterization of Crohn disease in X-linked inhibitor of apoptosis-deficient male patients and female symptomatic carriers. J Allergy Clin Immunol. 2014 Nov;134(5):1131-41.e9. doi:, 10.1016/j.jaci.2014.04.031. Epub 2014 Jun 15. PMID:24942515 doi:http://dx.doi.org/10.1016/j.jaci.2014.04.031
- ↑ Ardley HC, Robinson PA. The role of ubiquitin-protein ligases in neurodegenerative disease. Neurodegener Dis. 2004;1(2-3):71-87. PMID:16908979 doi:http://dx.doi.org/10.1159/000080048
- ↑ Xu G, Jiang X, Jaffrey SR. A mental retardation-linked nonsense mutation in cereblon is rescued by proteasome inhibition. J Biol Chem. 2013 Oct 11;288(41):29573-85. doi: 10.1074/jbc.M113.472092. Epub, 2013 Aug 27. PMID:23983124 doi:http://dx.doi.org/10.1074/jbc.M113.472092
- ↑ Lu G, Middleton RE, Sun H, Naniong M, Ott CJ, Mitsiades CS, Wong KK, Bradner JE, Kaelin WG Jr. The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins. Science. 2014 Jan 17;343(6168):305-9. doi: 10.1126/science.1244917. Epub 2013 Nov, 29. PMID:24292623 doi:http://dx.doi.org/10.1126/science.1244917
- ↑ Stieglitz B, Rana RR, Koliopoulos MG, Morris-Davies AC, Schaeffer V, Christodoulou E, Howell S, Brown NR, Dikic I, Rittinger K. Structural basis for ligase-specific conjugation of linear ubiquitin chains by HOIP. Nature. 2013 Oct 20. doi: 10.1038/nature12638. PMID:24141947 doi:http://dx.doi.org/10.1038/nature12638
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