5b2y

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'''Unreleased structure'''
 
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The entry 5b2y is ON HOLD until Paper Publication
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==Crystal Structure of P450BM3 with N-perfluorodecanoyl-L-tryptophan==
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<StructureSection load='5b2y' size='340' side='right' caption='[[5b2y]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
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Authors: Cong, Z., Shoji, O., Kasai, C., Sugimoto, H., Shiro, Y., Watanabe, Y.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5b2y]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5B2Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5B2Y FirstGlance]. <br>
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Description: Crystal Structure of P450BM3 with N-perfluorodecanoyl-L-tryptophan
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=W10:(2~{S})-3-(1~{H}-INDOL-3-YL)-2-[2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-NONADECAKIS(FLUORANYL)DECANOYLAMINO]PROPANOIC+ACID'>W10</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3wsp|3wsp]], [[5b2u|5b2u]], [[5b2v|5b2v]], [[5b2w|5b2w]], [[5b2x|5b2x]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5b2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5b2y OCA], [http://pdbe.org/5b2y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5b2y RCSB], [http://www.ebi.ac.uk/pdbsum/5b2y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5b2y ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/CPXB_BACMB CPXB_BACMB]] Functions as a fatty acid monooxygenase (PubMed:3106359, PubMed:1727637, PubMed:16566047, PubMed:7578081, PubMed:11695892, PubMed:14653735, PubMed:16403573, PubMed:18004886, PubMed:17077084, PubMed:17868686, PubMed:18298086, PubMed:18619466, PubMed:18721129, PubMed:19492389, PubMed:20180779, PubMed:21110374, PubMed:21875028). Catalyzes hydroxylation of fatty acids at omega-1, omega-2 and omega-3 positions (PubMed:1727637, PubMed:21875028). Shows activity toward medium and long-chain fatty acids, with optimum chain lengths of 12, 14 and 16 carbons (lauric, myristic, and palmitic acids). Able to metabolize some of these primary metabolites to secondary and tertiary products (PubMed:1727637). Marginal activity towards short chain lengths of 8-10 carbons (PubMed:1727637, PubMed:18619466). Hydroxylates highly branched fatty acids, which play an essential role in membrane fluidity regulation (PubMed:16566047). Also displays a NADPH-dependent reductase activity in the C-terminal domain, which allows electron transfer from NADPH to the heme iron of the cytochrome P450 N-terminal domain (PubMed:3106359, PubMed:1727637, PubMed:16566047, PubMed:7578081, PubMed:11695892, PubMed:14653735, PubMed:16403573, PubMed:18004886, PubMed:17077084, PubMed:17868686, PubMed:18298086, PubMed:18619466, PubMed:18721129, PubMed:19492389, PubMed:20180779, PubMed:21110374, PubMed:21875028). Involved in inactivation of quorum sensing signals of other competing bacteria by oxidazing efficiently acyl homoserine lactones (AHLs), molecules involved in quorum sensing signaling pathways, and their lactonolysis products acyl homoserines (AHs) (PubMed:18020460).<ref>PMID:11695892</ref> <ref>PMID:14653735</ref> <ref>PMID:16403573</ref> <ref>PMID:16566047</ref> <ref>PMID:17077084</ref> <ref>PMID:1727637</ref> <ref>PMID:17868686</ref> <ref>PMID:18004886</ref> <ref>PMID:18020460</ref> <ref>PMID:18298086</ref> <ref>PMID:18619466</ref> <ref>PMID:18721129</ref> <ref>PMID:19492389</ref> <ref>PMID:20180779</ref> <ref>PMID:21110374</ref> <ref>PMID:21875028</ref> <ref>PMID:3106359</ref> <ref>PMID:7578081</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Cong, Z]]
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[[Category: Kasai, C]]
[[Category: Shiro, Y]]
[[Category: Shiro, Y]]
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[[Category: Shoji, O]]
[[Category: Sugimoto, H]]
[[Category: Sugimoto, H]]
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[[Category: Cong, Z]]
 
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[[Category: Shoji, O]]
 
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[[Category: Kasai, C]]
 
[[Category: Watanabe, Y]]
[[Category: Watanabe, Y]]
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[[Category: Cytochrome p450]]
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[[Category: Oxidoreductase]]

Revision as of 09:20, 10 March 2017

Crystal Structure of P450BM3 with N-perfluorodecanoyl-L-tryptophan

5b2y, resolution 2.01Å

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