1s68

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[[Image:1s68.jpg|left|200px]]
[[Image:1s68.jpg|left|200px]]
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{{Structure
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|PDB= 1s68 |SIZE=350|CAPTION= <scene name='initialview01'>1s68</scene>, resolution 1.90&Aring;
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The line below this paragraph, containing "STRUCTURE_1s68", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE= Y10A, 24.1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10665 Enterobacteria phage T4])
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|DOMAIN=
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{{STRUCTURE_1s68| PDB=1s68 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s68 OCA], [http://www.ebi.ac.uk/pdbsum/1s68 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1s68 RCSB]</span>
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'''Structure and Mechanism of RNA Ligase'''
'''Structure and Mechanism of RNA Ligase'''
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[[Category: Shuman, S.]]
[[Category: Shuman, S.]]
[[Category: Wang, L K.]]
[[Category: Wang, L K.]]
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[[Category: ribonucleic acid ligase]]
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[[Category: Ribonucleic acid ligase]]
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[[Category: rna repair]]
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[[Category: Rna repair]]
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[[Category: t4]]
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[[Category: T4]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:21:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:37:59 2008''
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Revision as of 05:21, 3 May 2008

Image:1s68.jpg

Template:STRUCTURE 1s68

Structure and Mechanism of RNA Ligase


Overview

T4 RNA ligase 2 (Rnl2) exemplifies an RNA ligase family that includes the RNA editing ligases (RELs) of Trypanosoma and Leishmania. The Rnl2/REL enzymes are defined by essential signature residues and a unique C-terminal domain, which we show is essential for sealing of 3'-OH and 5'-PO4 RNA ends by Rnl2, but not for ligase adenylation or phosphodiester bond formation at a preadenylated AppRNA end. The N-terminal segment Rnl2(1-249) of the 334 aa Rnl2 protein comprises an autonomous adenylyltransferase/AppRNA ligase domain. We report the 1.9 A crystal structure of the ligase domain with AMP bound at the active site, which reveals a shared fold, catalytic mechanism, and evolutionary history for RNA ligases, DNA ligases, and mRNA capping enzymes.

About this Structure

1S68 is a Single protein structure of sequence from Enterobacteria phage t4. Full crystallographic information is available from OCA.

Reference

Structure and mechanism of RNA ligase., Ho CK, Wang LK, Lima CD, Shuman S, Structure. 2004 Feb;12(2):327-39. PMID:14962393 Page seeded by OCA on Sat May 3 08:21:15 2008

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