1s6a
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:1s6a.jpg|left|200px]] | [[Image:1s6a.jpg|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_1s6a", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | + | or leave the SCENE parameter empty for the default display. | |
| - | + | --> | |
| - | + | {{STRUCTURE_1s6a| PDB=1s6a | SCENE= }} | |
| - | | | + | |
| - | + | ||
| - | }} | + | |
'''The X-ray structure of the cyanobacteria Synechocystis hemoglobin "cyanoglobin" with azide ligand''' | '''The X-ray structure of the cyanobacteria Synechocystis hemoglobin "cyanoglobin" with azide ligand''' | ||
| Line 30: | Line 27: | ||
[[Category: Kundu, S.]] | [[Category: Kundu, S.]] | ||
[[Category: 2 on 2 helical fold]] | [[Category: 2 on 2 helical fold]] | ||
| - | [[Category: | + | [[Category: Cyanobacteria]] |
| - | [[Category: | + | [[Category: Globin]] |
| - | [[Category: | + | [[Category: Heme]] |
| - | [[Category: | + | [[Category: Hemoglobin]] |
| - | [[Category: | + | [[Category: Hexacoordinate]] |
| - | [[Category: | + | [[Category: Iron]] |
| - | [[Category: | + | [[Category: Oxygen binding]] |
| - | [[Category: | + | [[Category: Truncated]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:21:18 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 05:21, 3 May 2008
The X-ray structure of the cyanobacteria Synechocystis hemoglobin "cyanoglobin" with azide ligand
Overview
The crystal structures of cyanide and azide-bound forms of the truncated hemoglobin from Synechocystis are presented at 1.8 angstroms resolution. A comparison with the structure of the endogenously liganded protein reveals a conformational shift unprecedented in hemoglobins, and provides the first picture of a hexacoordinate hemoglobin in both the bis-histidyl and the exogenously coordinated states. The structural changes between the different conformations are confined to two regions of the protein; the B helix, and the E helix, including the EF loop. A molecular "hinge" controlling movement of the E helix is observed in the EF loop, which is composed of three principal structural elements: Arg64, the heme-d-propionate, and a three-residue extension of the F helix. Additional features of the structural transition between the two protein conformations are discussed as they relate to the complex ligand-binding behavior observed in hexacoordinate hemoglobins, and the potential physiological function of this class of proteins.
About this Structure
1S6A is a Single protein structure of sequence from Synechocystis sp.. Full crystallographic information is available from OCA.
Reference
Crystallographic analysis of synechocystis cyanoglobin reveals the structural changes accompanying ligand binding in a hexacoordinate hemoglobin., Trent JT 3rd, Kundu S, Hoy JA, Hargrove MS, J Mol Biol. 2004 Aug 20;341(4):1097-108. PMID:15289104 Page seeded by OCA on Sat May 3 08:21:18 2008
