1s7m
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:1s7m.gif|left|200px]] | [[Image:1s7m.gif|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_1s7m", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | + | or leave the SCENE parameter empty for the default display. | |
| - | + | --> | |
| - | + | {{STRUCTURE_1s7m| PDB=1s7m | SCENE= }} | |
| - | + | ||
| - | | | + | |
| - | }} | + | |
'''Crystal Structure of HiaBD1''' | '''Crystal Structure of HiaBD1''' | ||
| Line 31: | Line 28: | ||
[[Category: Waksman, G.]] | [[Category: Waksman, G.]] | ||
[[Category: Yeo, H J.]] | [[Category: Yeo, H J.]] | ||
| - | [[Category: | + | [[Category: Adhesion]] |
| - | [[Category: | + | [[Category: Autotransporter]] |
| - | [[Category: | + | [[Category: Homotrimer]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:23:55 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 05:23, 3 May 2008
Crystal Structure of HiaBD1
Overview
Haemophilus influenzae is an important human pathogen that initiates infection by colonizing the upper respiratory tract. The H. influenzae Hia autotransporter is an adhesive protein that promotes adherence to respiratory epithelial cells. Hia adhesive activity resides in two homologous binding domains, called HiaBD1 and HiaBD2. These domains interact with the same host cell receptor, but bind with different affinities. In this report, we describe the crystal structure of the high-affinity HiaBD1 binding domain, which has a novel trimeric architecture with three-fold symmetry and a mushroom shape. The subunit constituents of the trimer are extensively intertwined. The receptor-binding pocket is formed by an acidic patch that is present on all three faces of the trimer, providing potential for a multivalent interaction with the host cell surface, analogous to observations with the trimeric tumor necrosis factor superfamily of proteins. Hia is a novel example of a bacterial trimeric adhesin and may be the prototype member of a large family of bacterial virulence proteins with a similar architecture.
About this Structure
1S7M is a Single protein structure of sequence from Haemophilus influenzae. Full crystallographic information is available from OCA.
Reference
Structural basis for host recognition by the Haemophilus influenzae Hia autotransporter., Yeo HJ, Cotter SE, Laarmann S, Juehne T, St Geme JW 3rd, Waksman G, EMBO J. 2004 Mar 24;23(6):1245-56. Epub 2004 Mar 18. PMID:15029242 Page seeded by OCA on Sat May 3 08:23:55 2008
