This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1s8f

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1s8f.gif|left|200px]]
[[Image:1s8f.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1s8f |SIZE=350|CAPTION= <scene name='initialview01'>1s8f</scene>, resolution 1.77&Aring;
+
The line below this paragraph, containing "STRUCTURE_1s8f", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GDP:GUANOSINE-5&#39;-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SR:STRONTIUM+ION'>SR</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE= RAB9A, RAB9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9615 Canis lupus familiaris])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1s8f| PDB=1s8f | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s8f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s8f OCA], [http://www.ebi.ac.uk/pdbsum/1s8f PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1s8f RCSB]</span>
+
-
}}
+
'''Crystal structure of Rab9 complexed to GDP reveals a dimer with an active conformation of switch II'''
'''Crystal structure of Rab9 complexed to GDP reveals a dimer with an active conformation of switch II'''
Line 27: Line 24:
[[Category: Rudolph, M G.]]
[[Category: Rudolph, M G.]]
[[Category: Wittmann, J G.]]
[[Category: Wittmann, J G.]]
-
[[Category: hemihedral twinning]]
+
[[Category: Hemihedral twinning]]
-
[[Category: intracellular transport]]
+
[[Category: Intracellular transport]]
-
[[Category: vesicular trafficking]]
+
[[Category: Vesicular trafficking]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:25:27 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:38:49 2008''
+

Revision as of 05:25, 3 May 2008

Image:1s8f.gif

Template:STRUCTURE 1s8f

Crystal structure of Rab9 complexed to GDP reveals a dimer with an active conformation of switch II


Overview

The small GTPase Rab9 is an essential regulator of vesicular transport from the late endosome to the trans-Golgi network, as monitored by the redirection of the mannose-6-phosphate receptors. The crystal structure of Rab9 complexed to GDP, Mg(2+), and Sr(2+) reveals a unique dimer formed by an intermolecular beta-sheet that buries the switch I regions. Surface area and shape complementarity calculations suggest that Rab9 dimers can form an inactive, membrane-bound pool of Rab9 . GDP that is independent of GDI. Mg(2+)-bound Rab9 represents an inactive state, but Sr(2+)-bound Rab9 . GDP displays activated switch region conformations, mimicking those of the GTP state. A hydrophobic tetrad is formed resembling an effector-discriminating epitope found only in GTP-bound Rab proteins.

About this Structure

1S8F is a Single protein structure of sequence from Canis lupus familiaris. Full crystallographic information is available from OCA.

Reference

Crystal structure of Rab9 complexed to GDP reveals a dimer with an active conformation of switch II., Wittmann JG, Rudolph MG, FEBS Lett. 2004 Jun 18;568(1-3):23-9. PMID:15196914 Page seeded by OCA on Sat May 3 08:25:27 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1s8f"
Personal tools