5hyc
From Proteopedia
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<StructureSection load='5hyc' size='340' side='right' caption='[[5hyc]], [[Resolution|resolution]] 2.40Å' scene=''> | <StructureSection load='5hyc' size='340' side='right' caption='[[5hyc]], [[Resolution|resolution]] 2.40Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5hyc]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HYC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HYC FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5hyc]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mago7 Mago7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HYC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HYC FirstGlance]. <br> |
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5hxl|5hxl]]</td></tr> | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5hxl|5hxl]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MGG_01005 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=242507 MAGO7])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hyc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hyc OCA], [http://pdbe.org/5hyc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hyc RCSB], [http://www.ebi.ac.uk/pdbsum/5hyc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hyc ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hyc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hyc OCA], [http://pdbe.org/5hyc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hyc RCSB], [http://www.ebi.ac.uk/pdbsum/5hyc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hyc ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Magnaporthe oryzae is a model fungal plant pathogen employed for studying plant-fungi interactions. Whole genome sequencing and bioinformatics analyses revealed that this fungal pathogen has more than 12,000 protein-coding genes with 65% of the genes remaining functionally un-annotated. Here, we determine the structure of the hypothetical protein, MGG_01005 and show that it is the Magnaporthe oryzae Dynein light chain Tctex-type 1 (dynlt1/3), demonstrated by its structural similarity to other orthologous dynlt1 proteins and its conserved interaction with the N-terminus of the Magnaporthe oryzae dynein intermediate chain, MoDyn1I2. In addition, we present the structure of the MGG_01005-MoDyn1I2 complex together with mutagenesis studies that reveals a di-histidine motif interaction with a glutamate residue in the dynein intermediate chain within a conserved molecular interface. These results demonstrate the utility of structure-based annotation and validate it as a viable approach for the molecular assignment of hypothetic proteins from phyto-pathogenic fungi. | ||
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| + | Structure based function-annotation of hypothetical protein MGG_01005 from Magnaporthe oryzae reveals it is the dynein light chain orthologue of dynlt1/3.,Li G, Huang J, Yang J, He D, Wang C, Qi X, Taylor IA, Liu J, Peng YL Sci Rep. 2018 Mar 2;8(1):3952. doi: 10.1038/s41598-018-21667-5. PMID:29500373<ref>PMID:29500373</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 5hyc" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Dynein|Dynein]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Mago7]] | ||
[[Category: Huang, J]] | [[Category: Huang, J]] | ||
[[Category: Li, G]] | [[Category: Li, G]] | ||
Revision as of 06:56, 28 March 2018
Structure based function annotation of a hypothetical protein MGG_01005 related to the development of rice blast fungus
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