1s95

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[[Image:1s95.gif|left|200px]]
[[Image:1s95.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1s95 |SIZE=350|CAPTION= <scene name='initialview01'>1s95</scene>, resolution 1.60&Aring;
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The line below this paragraph, containing "STRUCTURE_1s95", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= PPP5C, PPP5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_1s95| PDB=1s95 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s95 OCA], [http://www.ebi.ac.uk/pdbsum/1s95 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1s95 RCSB]</span>
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}}
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'''Structure of serine/threonine protein phosphatase 5'''
'''Structure of serine/threonine protein phosphatase 5'''
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[[Category: Honkanen, R E.]]
[[Category: Honkanen, R E.]]
[[Category: Swingle, M R.]]
[[Category: Swingle, M R.]]
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[[Category: metal ion]]
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[[Category: Metal ion]]
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[[Category: metallophosphoesterase]]
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[[Category: Metallophosphoesterase]]
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[[Category: phosphate anion]]
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[[Category: Phosphate anion]]
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[[Category: pp5]]
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[[Category: Pp5]]
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[[Category: pppase]]
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[[Category: Pppase]]
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[[Category: protein phosphatase]]
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[[Category: Protein phosphatase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:26:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:38:55 2008''
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Revision as of 05:26, 3 May 2008

Image:1s95.gif

Template:STRUCTURE 1s95

Structure of serine/threonine protein phosphatase 5


Overview

Serine/threonine protein phosphatase-5 (PP5) affects many signaling networks that regulate cell growth and cellular responses to stress. Here we report the crystal structure of the PP5 catalytic domain (PP5c) at a resolution of 1.6 A. From this structure we propose a mechanism for PP5-mediated hydrolysis of phosphoprotein substrates, which requires the precise positioning of two metal ions within a conserved Asp271-M1:M2-W1-His427-His304-Asp274 catalytic motif (where M1 and M2 are metals and W1 is a water molecule). The structure of PP5c provides a structural basis for explaining the exceptional catalytic proficiency of protein phosphatases, which are among the most powerful known catalysts. Resolution of the entire C terminus revealed a novel subdomain, and the structure of the PP5c should also aid development of type-specific inhibitors.

About this Structure

1S95 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for the catalytic activity of human serine/threonine protein phosphatase-5., Swingle MR, Honkanen RE, Ciszak EM, J Biol Chem. 2004 Aug 6;279(32):33992-9. Epub 2004 May 23. PMID:15155720 Page seeded by OCA on Sat May 3 08:26:16 2008

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