1sbs

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[[Image:1sbs.gif|left|200px]]
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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sbs OCA], [http://www.ebi.ac.uk/pdbsum/1sbs PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1sbs RCSB]</span>
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'''CRYSTAL STRUCTURE OF AN ANTI-HCG FAB'''
'''CRYSTAL STRUCTURE OF AN ANTI-HCG FAB'''
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[[Category: Isaacs, N W.]]
[[Category: Isaacs, N W.]]
[[Category: Schielen, W J.G.]]
[[Category: Schielen, W J.G.]]
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[[Category: fab-fragment]]
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[[Category: Fab-fragment]]
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[[Category: monoclonal antibody]]
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[[Category: Monoclonal antibody]]
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[[Category: reproduction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:31:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:39:56 2008''
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Revision as of 05:31, 3 May 2008

Image:1sbs.gif

Template:STRUCTURE 1sbs

CRYSTAL STRUCTURE OF AN ANTI-HCG FAB


Overview

3A2 is an antibody raised against human chorionic gonadotropin and recognizes a linear epitope on the C-terminal peptide of the human chorionic gonadotropin beta-subunit. Its three-dimensional structure has been determined to 2-A resolution using molecular replacement and refined to a conventional R-factor of 18.2%. The protein exhibits the typical immunoglobulin fold, and the model contains 944 ordered water molecules and one sulfate ion. A comparison of the complementarity-determining regions of the Fab3A2 with those from the Protein Data Bank following the canonical structure method reveals a canonical main chain conformation. This antibody belongs to the canonical structure class (combination of canonical conformations of the complementarity determining loops) that shows a preference for haptens and not for peptides. However, the shape of the surface of the antigen binding loops resembles that of an anti-peptide antibody.

About this Structure

1SBS is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structure of an Fab fragment against a C-terminal peptide of hCG at 2.0 A resolution., Fotinou C, Beauchamp J, Emsley P, deHaan A, Schielen WJ, Bos E, Isaacs NW, J Biol Chem. 1998 Aug 28;273(35):22515-8. PMID:9712877 Page seeded by OCA on Sat May 3 08:31:23 2008

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