Sandbox Reserved 1302
From Proteopedia
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==Interactions== | ==Interactions== | ||
| - | + | Zinc fingers are found in eukaryotic nucleus interacting with the outside of B-DNA. When interacting with DNA, the zinc fingers bind in the major groove of B-DNA and wrap part way around the double helix. | |
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==References== | ==References== | ||
Revision as of 21:15, 8 February 2017
Contents |
Zinc-finger 1
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Origin
Zinc fingers were first identified in a study of transcription in the transcription factor TFIIIA of the African clawed frog, Xenopus laevis, conducted in Aaron Klug's lab.
Structure
The “finger” refers to the secondary structures ( and ) that are held together by the .
Function
This small protein motif is a transcriptional regulator. It recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation. regulate eukaryotic gene expression
Interactions
Zinc fingers are found in eukaryotic nucleus interacting with the outside of B-DNA. When interacting with DNA, the zinc fingers bind in the major groove of B-DNA and wrap part way around the double helix.
References
Zinc Fingers. (n.d.). Retrieved February 08, 2017, from http://www.ebi.ac.uk/interpro/potm/2007_3/Page2.htm
