1sdb

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{{Structure
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|PDB= 1sdb |SIZE=350|CAPTION= <scene name='initialview01'>1sdb</scene>, resolution 1.65&Aring;
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The line below this paragraph, containing "STRUCTURE_1sdb", creates the "Structure Box" on the page.
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{{STRUCTURE_1sdb| PDB=1sdb | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sdb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sdb OCA], [http://www.ebi.ac.uk/pdbsum/1sdb PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1sdb RCSB]</span>
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'''PORCINE DESB1-2 DESPENTAPEPTIDE(B26-B30) INSULIN'''
'''PORCINE DESB1-2 DESPENTAPEPTIDE(B26-B30) INSULIN'''
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[[Category: Diao, J S.]]
[[Category: Diao, J S.]]
[[Category: Liang, D C.]]
[[Category: Liang, D C.]]
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[[Category: hormone]]
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[[Category: Hormone]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:34:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:40:34 2008''
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Revision as of 05:34, 3 May 2008

Image:1sdb.jpg

Template:STRUCTURE 1sdb

PORCINE DESB1-2 DESPENTAPEPTIDE(B26-B30) INSULIN


Overview

Insulin has a concentration of 10(-8)-10(-11) M in the blood which ensures that it circulates and exerts its physiological functions in vivo as a monomer. The crystal structure of monomeric porcine desB1-B2 despentapeptide (B26-B30) insulin (DesB1-2 DPI) with M(r) = 4934 Da has been determined at 1.65 A resolution using the molecular replacement method. A structural comparison between DesB1-2 DPI and 2Zn insulin reveals that the conformation of DesB1-2 DPI is more similar to molecule I than molecule II of 2Zn insulin. The remarkable conformational difference between B25-Phe in DesB1-2 DPI and B25-Phe in despentapeptide (B26-B30) insulin (DPI) indicates that the residue B25-Phe possesses great flexibility and mobility.

About this Structure

1SDB is a Protein complex structure of sequences from Sus scrofa. Full crystallographic information is available from OCA.

Reference

Structure of monomeric porcine DesB1-B2 despentapeptide (B26-B30) insulin at 1.65 A resolution., Diao JS, Wan ZL, Chang WR, Liang DC, Acta Crystallogr D Biol Crystallogr. 1997 Sep 1;53(Pt 5):507-12. PMID:15299880 Page seeded by OCA on Sat May 3 08:34:21 2008

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