Mutations in Brca1 BRCT Domains

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Line 312: Line 312:
</jmolLink>
</jmolLink>
</jmol> between the two states. This mutation causes overpacking.
</jmol> between the two states. This mutation causes overpacking.
-
*<scene name='75/752201/I1766s/1'>L1764S:</scene>
+
*<scene name='75/752201/I1766s/1'>Mutation I1766S:</scene>
<jmol>
<jmol>
<jmolLink>
<jmolLink>
<script>
<script>
-
animation on; animation mode loop; frame 1 1 play; animation off; frame 1; select [LEU]1764;color selectionHalos green;selectionHalos on;
+
animation on; animation mode loop; frame 1 1 play; animation off; frame 1; select [ILE]1766;color selectionHalos green;selectionHalos on;
</script>
</script>
<text>Wild type </text>
<text>Wild type </text>
Line 325: Line 325:
<jmolLink>
<jmolLink>
<script>
<script>
-
animation on; animation mode loop; frame 2 2 play; animation off; frame 2; select [SER]1764;color selectionHalos red;selectionHalos on;
+
animation on; animation mode loop; frame 2 2 play; animation off; frame 2; select [SER]1766;color selectionHalos red;selectionHalos on;
</script>
</script>
<text>mutation.
<text>mutation.
Line 335: Line 335:
<jmolLink>
<jmolLink>
<script>
<script>
-
animation off; frame all; select [SER]1764;color selectionHalos red;selectionHalos on;
+
animation off; frame all; select [SER]1766;color selectionHalos red;selectionHalos on;
</script>
</script>
<text>mutated and wild type
<text>mutated and wild type
Line 344: Line 344:
<jmolLink>
<jmolLink>
<script>
<script>
-
animation on; animation mode loop; frame play; select [SER]1764;color selectionHalos red;selectionHalos on;
+
animation on; animation mode loop; frame play; select [SER]1766;color selectionHalos red;selectionHalos on;
</script>
</script>
<text>animation
<text>animation

Revision as of 10:18, 16 February 2017

Drag the structure with the mouse to rotate

References

  1. ↑ Clapperton JA, Manke IA, Lowery DM, Ho T, Haire LF, Yaffe MB, Smerdon SJ. Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer. Nat Struct Mol Biol. 2004 Jun;11(6):512-8. Epub 2004 May 9. PMID:15133502 doi:10.1038/nsmb775
  2. ↑ Williams RS, Glover JN. Structural consequences of a cancer-causing BRCA1-BRCT missense mutation. J Biol Chem. 2003 Jan 24;278(4):2630-5. Epub 2002 Nov 8. PMID:12427738 doi:10.1074/jbc.M210019200

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel, Joel L. Sussman

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