AMP-activated protein kinase

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Line 73: Line 73:
**[[4qfg]] – rAMPK (mutant) + AMP + staurosporine <br />
**[[4qfg]] – rAMPK (mutant) + AMP + staurosporine <br />
-
**[[4qfr]], [[4qfs]] – rAMPK (mutant) + AMP + ADP + staurosporine + activator<br />
+
**[[5ufu]] – rAMPK + AMP + ADP + staurosporine + activator<br />
 +
**[[4qfr]], [[4qfs]], [[5t5t]] – rAMPK (mutant) + AMP + ADP + staurosporine + activator<br />
**[[5kq5]] – rAMPK + AMP + ADP + staurosporine + activator<br />
**[[5kq5]] – rAMPK + AMP + ADP + staurosporine + activator<br />
*Phosphorylated AMPK α-2+β-1+γ-1
*Phosphorylated AMPK α-2+β-1+γ-1
-
**[[4cfe]] – hAMPK + AMP + staurosporine + benzimidazole derivative<br />
+
**[[4cfe]], [[5iso]] – hAMPK + AMP + staurosporine + benzimidazole derivative<br />
**[[4cff]] – hAMPK + AMP + staurosporine + pyridone derivative<br />
**[[4cff]] – hAMPK + AMP + staurosporine + pyridone derivative<br />
**[[4zhx]], [[5ezv]] – hAMPK + AMP + staurosporine + furan-2-posphonic derivative<br />
**[[4zhx]], [[5ezv]] – hAMPK + AMP + staurosporine + furan-2-posphonic derivative<br />

Revision as of 11:24, 13 March 2018

Human AMP-activated protein kinase α1 subunit (deeppink) +β2 subunit (green) +γ1 subunit (cyan) complex with AMP, staurosporine, cyclodextrin and HEPES (PDB code 4rer)

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3D structures of AMP-activated protein kinase

Updated on 13-March-2018

References

  1. ↑ Li X, Wang L, Zhou XE, Ke J, de Waal PW, Gu X, Tan MH, Wang D, Wu D, Xu HE, Melcher K. Structural basis of AMPK regulation by adenine nucleotides and glycogen. Cell Res. 2014 Nov 21. doi: 10.1038/cr.2014.150. PMID:25412657 doi:http://dx.doi.org/10.1038/cr.2014.150

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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