Apoptosis-inducing factor

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Revision as of 19:55, 18 October 2017

spinqualitylabelsall models Human apoptosis-inducing factor complex with FAD, NAD and sulfate (PDB code 4bur) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Apoptosis-inducing factor (AIF) is an intermembrane flavoprotein which induces caspase-independent peripheral chromatin condensation and large-scale DNA fragmentation and thus causes cell death[1]. AIF contains the cofactor FAD. Relevance AIF deficiency is a risk factor for the development of diabetic kidney disease[2]. Structural highlights The AIF binding site contains the cofactor and 2 molecules of the reducing factor NADH[3]. Water molecules shown as red spheres. . . . .

3D structures of apoptosis-inducing factor

Updated on 18-October-2017

4bv6, 4lii, 1m6i – hAIF – human
5fmh, 5kvh, 5kvi, 5fs6, 5fs7, 5fs8, 4fdc – hAIF (mutant)
5fs9 – hAIF (mutant) + FAD
4bur – hAIF + NAD
3gd3, 1gv4 – mAIF – mouse
3gd4 – mAIF + NAD

References

1. ↑ Cande C, Cohen I, Daugas E, Ravagnan L, Larochette N, Zamzami N, Kroemer G. Apoptosis-inducing factor (AIF): a novel caspase-independent death effector released from mitochondria. Biochimie. 2002 Feb-Mar;84(2-3):215-22. PMID:12022952
2. ↑ Coughlan MT, Higgins GC, Nguyen TV, Penfold SA, Thallas-Bonke V, Tan SM, Ramm G, Van Bergen NJ, Henstridge DC, Sourris KC, Harcourt BE, Trounce IA, Robb PM, Laskowski A, McGee SL, Genders AJ, Walder K, Drew BG, Gregorevic P, Qian H, Thomas MC, Jerums G, Macisaac RJ, Skene A, Power DA, Ekinci EI, Wijeyeratne XW, Gallo LA, Herman-Edelstein M, Ryan MT, Cooper ME, Thorburn DR, Forbes JM. Deficiency in Apoptosis-Inducing Factor Recapitulates Chronic Kidney Disease via Aberrant Mitochondrial Homeostasis. Diabetes. 2016 Apr;65(4):1085-98. doi: 10.2337/db15-0864. Epub 2016 Jan 28. PMID:26822084 doi:http://dx.doi.org/10.2337/db15-0864
3. ↑ Ferreira P, Villanueva R, Martinez-Julvez M, Herguedas B, Marcuello C, Fernandez-Silva P, Cabon L, Hermoso JA, Lostao A, Susin SA, Medina M. Structural insights into the coenzyme mediated monomer-dimer transition of the pro-apoptotic apoptosis inducing factor. Biochemistry. 2014 Jul 1;53(25):4204-15. doi: 10.1021/bi500343r. Epub 2014 Jun, 20. PMID:24914854 doi:http://dx.doi.org/10.1021/bi500343r