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1sjm
From Proteopedia
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[[Image:1sjm.gif|left|200px]] | [[Image:1sjm.gif|left|200px]] | ||
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'''Nitrite bound copper containing nitrite reductase''' | '''Nitrite bound copper containing nitrite reductase''' | ||
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Side-on copper-nitrosyl coordination by nitrite reductase., Tocheva EI, Rosell FI, Mauk AG, Murphy ME, Science. 2004 May 7;304(5672):867-70. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15131305 15131305] | Side-on copper-nitrosyl coordination by nitrite reductase., Tocheva EI, Rosell FI, Mauk AG, Murphy ME, Science. 2004 May 7;304(5672):867-70. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15131305 15131305] | ||
[[Category: Alcaligenes faecalis]] | [[Category: Alcaligenes faecalis]] | ||
| - | [[Category: Nitrite reductase (NO-forming)]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Mauk, A G.]] | [[Category: Mauk, A G.]] | ||
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[[Category: Rosell, F I.]] | [[Category: Rosell, F I.]] | ||
[[Category: Tocheva, E I.]] | [[Category: Tocheva, E I.]] | ||
| - | [[Category: | + | [[Category: Copper]] |
| - | [[Category: | + | [[Category: Nitrite]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:47:10 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 05:47, 3 May 2008
Nitrite bound copper containing nitrite reductase
Overview
A copper-nitrosyl intermediate forms during the catalytic cycle of nitrite reductase, the enzyme that mediates the committed step in bacterial denitrification. The crystal structure of a type 2 copper-nitrosyl complex of nitrite reductase reveals an unprecedented side-on binding mode in which the nitrogen and oxygen atoms are nearly equidistant from the copper cofactor. Comparison of this structure with a refined nitrite-bound crystal structure explains how coordination can change between copper-oxygen and copper-nitrogen during catalysis. The side-on copper-nitrosyl in nitrite reductase expands the possibilities for nitric oxide interactions in copper proteins such as superoxide dismutase and prions.
About this Structure
1SJM is a Single protein structure of sequence from Alcaligenes faecalis. Full crystallographic information is available from OCA.
Reference
Side-on copper-nitrosyl coordination by nitrite reductase., Tocheva EI, Rosell FI, Mauk AG, Murphy ME, Science. 2004 May 7;304(5672):867-70. PMID:15131305 Page seeded by OCA on Sat May 3 08:47:10 2008
