5fzf

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 5fzf is ON HOLD until Paper Publication
+
==Crystal structure of the catalytic domain of human JARID1B in complex with MC3962==
-
 
+
<StructureSection load='5fzf' size='340' side='right' caption='[[5fzf]], [[Resolution|resolution]] 1.97&Aring;' scene=''>
-
Authors: Nowak, R., Krojer, T., Johansson, C., Gileadi, C., Kupinska, K., Strain-Damerell, C., Szykowska, A., Von Delft, F., Burgess-Brown, N.A., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Rotili, D., Mai, A., Oppermann, U.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[5fzf]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FZF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FZF FirstGlance]. <br>
-
Description: Crystal structure of the catalytic domain of human JARID1B in complex with MC3962
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=UUN:N-HYDROXY-2-[(6-OXO-4-PHENYL-1,6-DIHYDROPYRIMIDIN-2-YL)SULFANYL]ACETAMIDE'>UUN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5fyc|5fyc]], [[5fyh|5fyh]], [[5fyi|5fyi]], [[5fym|5fym]], [[5fys|5fys]], [[5fyt|5fyt]], [[5fyu|5fyu]], [[5fyv|5fyv]], [[5fyy|5fyy]], [[5fyz|5fyz]], [[5fz0|5fz0]], [[5fz1|5fz1]], [[5fz3|5fz3]], [[5fz4|5fz4]], [[5fz6|5fz6]], [[5fz7|5fz7]], [[5fz8|5fz8]], [[5fz9|5fz9]], [[5fza|5fza]], [[5fzb|5fzb]], [[5fzc|5fzc]], [[5fzd|5fzd]], [[5fze|5fze]], [[5fzg|5fzg]], [[5fzh|5fzh]], [[5fzi|5fzi]], [[5fzk|5fzk]], [[5fzl|5fzl]], [[5fzm|5fzm]], [[5fzo|5fzo]]</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fzf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fzf OCA], [http://pdbe.org/5fzf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fzf RCSB], [http://www.ebi.ac.uk/pdbsum/5fzf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fzf ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[[http://www.uniprot.org/uniprot/KDM5B_HUMAN KDM5B_HUMAN]] Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.<ref>PMID:12657635</ref> <ref>PMID:16645588</ref> <ref>PMID:17320161</ref> <ref>PMID:17363312</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Arrowsmith, C H]]
 +
[[Category: Bountra, C]]
 +
[[Category: Burgess-Brown, N A]]
 +
[[Category: Delft, F Von]]
 +
[[Category: Edwards, A M]]
 +
[[Category: Gileadi, C]]
 +
[[Category: Johansson, C]]
 +
[[Category: Krojer, T]]
 +
[[Category: Kupinska, K]]
 +
[[Category: Mai, A]]
[[Category: Nowak, R]]
[[Category: Nowak, R]]
-
[[Category: Arrowsmith, C.H]]
 
-
[[Category: Gileadi, C]]
 
[[Category: Oppermann, U]]
[[Category: Oppermann, U]]
[[Category: Rotili, D]]
[[Category: Rotili, D]]
 +
[[Category: Strain-Damerell, C]]
[[Category: Szykowska, A]]
[[Category: Szykowska, A]]
-
[[Category: Burgess-Brown, N.A]]
+
[[Category: Jarid1b]]
-
[[Category: Von Delft, F]]
+
[[Category: Oxidoreductase]]
-
[[Category: Edwards, A.M]]
+
[[Category: Plu1]]
-
[[Category: Johansson, C]]
+
-
[[Category: Mai, A]]
+
-
[[Category: Strain-Damerell, C]]
+
-
[[Category: Krojer, T]]
+
-
[[Category: Bountra, C]]
+
-
[[Category: Kupinska, K]]
+

Revision as of 13:42, 29 March 2017

Crystal structure of the catalytic domain of human JARID1B in complex with MC3962

5fzf, resolution 1.97Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5fzf"
Personal tools