5jwe
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of H-2Db in complex with the LCMV-derived GP92-101 peptide== | |
| - | + | <StructureSection load='5jwe' size='340' side='right' caption='[[5jwe]], [[Resolution|resolution]] 2.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5jwe]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JWE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JWE FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jwe OCA], [http://pdbe.org/5jwe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jwe RCSB], [http://www.ebi.ac.uk/pdbsum/5jwe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jwe ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/HA11_MOUSE HA11_MOUSE]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/GLYC_LYCVA GLYC_LYCVA]] Stable signal peptide (SSP) is cleaved but is apparently retained as the third component of the GP complex. The SSP is required for efficient glycoprotein expression, post-translational cleavage of GP1 and GP2, glycoprotein transport to the cell plasma membrane, formation of infectious virus particles, and acid pH-dependent glycoprotein-mediated cell fusion.<ref>PMID:17376927</ref> Glycoprotein G1 mediates virus attachment to host receptor alpha-dystroglycan DAG1. This attachment induces virion internalization predominantly through clathrin- and caveolin-independent endocytosis.<ref>PMID:9851928</ref> Glycoprotein G2 is a class I viral fusion protein, that directs fusion of viral and host endosomal membranes, leading to delivery of the nucleocapsid into the cytoplasm. Membrane fusion is mediated by irreversable conformational changes induced upon acidification in the endosome.<ref>PMID:8291229</ref> [[http://www.uniprot.org/uniprot/B2MG_MOUSE B2MG_MOUSE]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Achour, A]] | [[Category: Achour, A]] | ||
| + | [[Category: Badia-Martinez, D]] | ||
[[Category: Buratto, J]] | [[Category: Buratto, J]] | ||
[[Category: Norstrom, M]] | [[Category: Norstrom, M]] | ||
| - | [[Category: Badia-Martinez, D]] | ||
[[Category: Sandalova, T]] | [[Category: Sandalova, T]] | ||
| + | [[Category: Antigen presentation]] | ||
| + | [[Category: Immune system]] | ||
| + | [[Category: Immunology]] | ||
| + | [[Category: Mhc class i]] | ||
Revision as of 13:44, 24 May 2017
Crystal structure of H-2Db in complex with the LCMV-derived GP92-101 peptide
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