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5l1y
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Solution structure of a Bcl-xL S62E mutant== | |
| - | + | <StructureSection load='5l1y' size='340' side='right' caption='[[5l1y]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5l1y]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L1Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L1Y FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l1y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l1y OCA], [http://pdbe.org/5l1y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l1y RCSB], [http://www.ebi.ac.uk/pdbsum/5l1y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l1y ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Follis, A V]] | ||
[[Category: Kriwacki, R]] | [[Category: Kriwacki, R]] | ||
| - | [[Category: | + | [[Category: Apoptosis]] |
Revision as of 10:34, 7 October 2017
Solution structure of a Bcl-xL S62E mutant
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