5l76

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 5l76 is ON HOLD until Paper Publication
+
==Crystal structure of human aminoadipate semialdehyde synthase, saccharopine dehydrogenase domain (in apo form)==
-
 
+
<StructureSection load='5l76' size='340' side='right' caption='[[5l76]], [[Resolution|resolution]] 2.57&Aring;' scene=''>
-
Authors: Kopec, J., Pena, I.A., Rembeza, E., Strain-Damerell, C., Chalk, R., Borkowska, O., Goubin, S., Velupillai, S., Burgess-Brown, N., Arrowsmith, C., Edwards, A., Bountra, C., Arruda, P., Yue, W.W.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[5l76]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L76 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L76 FirstGlance]. <br>
-
Description: Crystal structure of human aminoadipate semialdehyde synthase, saccharopine dehydrogenase domain (in apo form)
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l76 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l76 OCA], [http://pdbe.org/5l76 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l76 RCSB], [http://www.ebi.ac.uk/pdbsum/5l76 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l76 ProSAT]</span></td></tr>
-
[[Category: Goubin, S]]
+
</table>
 +
== Disease ==
 +
[[http://www.uniprot.org/uniprot/AASS_HUMAN AASS_HUMAN]] Hyperlysinemia;Saccharopinuria. The disease is caused by mutations affecting the gene represented in this entry. The protein represented in this entry is involved in disease pathogenesis. A selective decrease in mitochondrial NADP(H) levels due to NADK2 mutations causes a deficiency of NADPH-dependent mitochondrial enzymes, such as DECR1 and AASS.<ref>PMID:24847004</ref>
 +
== Function ==
 +
[[http://www.uniprot.org/uniprot/AASS_HUMAN AASS_HUMAN]] Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively.
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Arrowsmith, C]]
 +
[[Category: Arruda, P]]
 +
[[Category: Borkowska, O]]
 +
[[Category: Bountra, C]]
[[Category: Burgess-Brown, N]]
[[Category: Burgess-Brown, N]]
[[Category: Chalk, R]]
[[Category: Chalk, R]]
-
[[Category: Borkowska, O]]
+
[[Category: Edwards, A]]
-
[[Category: Velupillai, S]]
+
[[Category: Goubin, S]]
-
[[Category: Yue, W.W]]
+
[[Category: Kopec, J]]
[[Category: Kopec, J]]
-
[[Category: Arrowsmith, C]]
+
[[Category: Pena, I A]]
-
[[Category: Arruda, P]]
+
[[Category: Rembeza, E]]
-
[[Category: Pena, I.A]]
+
-
[[Category: Edwards, A]]
+
[[Category: Strain-Damerell, C]]
[[Category: Strain-Damerell, C]]
-
[[Category: Rembeza, E]]
+
[[Category: Velupillai, S]]
-
[[Category: Bountra, C]]
+
[[Category: Yue, W W]]
 +
[[Category: Aass]]
 +
[[Category: Aminoadipate semialdehyde synthase]]
 +
[[Category: Oxidoreductase]]
 +
[[Category: Sdh]]

Revision as of 12:57, 10 May 2017

Crystal structure of human aminoadipate semialdehyde synthase, saccharopine dehydrogenase domain (in apo form)

5l76, resolution 2.57Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5l76"
Personal tools