5l78

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'''Unreleased structure'''
 
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The entry 5l78 is ON HOLD until Paper Publication
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==Crystal structure of human aminoadipate semialdehyde synthase, saccharopine dehydrogenase domain (in NAD+ bound form)==
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<StructureSection load='5l78' size='340' side='right' caption='[[5l78]], [[Resolution|resolution]] 2.68&Aring;' scene=''>
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Authors: Kopec, J., Pena, I.A., Rembeza, E., Strain-Damerell, C., Chalk, R., Borkowska, O., Goubin, S., Velupillai, S., Burgess-Brown, N., Arrowsmith, C., Edwards, A., Bountra, C., Arruda, P., Yue, W.W.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5l78]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L78 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L78 FirstGlance]. <br>
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Description: Crystal structure of human aminoadipate semialdehyde synthase, saccharopine dehydrogenase domain (in NAD+ bound form)
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l78 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l78 OCA], [http://pdbe.org/5l78 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l78 RCSB], [http://www.ebi.ac.uk/pdbsum/5l78 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l78 ProSAT]</span></td></tr>
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[[Category: Goubin, S]]
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/AASS_HUMAN AASS_HUMAN]] Hyperlysinemia;Saccharopinuria. The disease is caused by mutations affecting the gene represented in this entry. The protein represented in this entry is involved in disease pathogenesis. A selective decrease in mitochondrial NADP(H) levels due to NADK2 mutations causes a deficiency of NADPH-dependent mitochondrial enzymes, such as DECR1 and AASS.<ref>PMID:24847004</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/AASS_HUMAN AASS_HUMAN]] Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively.
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Arrowsmith, C]]
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[[Category: Arruda, P]]
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[[Category: Borkowska, O]]
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[[Category: Bountra, C]]
[[Category: Burgess-Brown, N]]
[[Category: Burgess-Brown, N]]
[[Category: Chalk, R]]
[[Category: Chalk, R]]
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[[Category: Borkowska, O]]
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[[Category: Edwards, A]]
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[[Category: Velupillai, S]]
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[[Category: Goubin, S]]
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[[Category: Yue, W.W]]
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[[Category: Kopec, J]]
[[Category: Kopec, J]]
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[[Category: Arrowsmith, C]]
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[[Category: Pena, I A]]
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[[Category: Arruda, P]]
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[[Category: Rembeza, E]]
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[[Category: Pena, I.A]]
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[[Category: Edwards, A]]
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[[Category: Strain-Damerell, C]]
[[Category: Strain-Damerell, C]]
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[[Category: Rembeza, E]]
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[[Category: Velupillai, S]]
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[[Category: Bountra, C]]
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[[Category: Yue, W W]]
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[[Category: Aass]]
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[[Category: Aminoadipate semialdehyde synthase]]
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[[Category: Oxidoreductase]]
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[[Category: Sdh]]

Revision as of 12:57, 10 May 2017

Crystal structure of human aminoadipate semialdehyde synthase, saccharopine dehydrogenase domain (in NAD+ bound form)

5l78, resolution 2.68Å

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