5lds
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the porcine aminopeptidase N ectodomain== | |
| - | + | <StructureSection load='5lds' size='340' side='right' caption='[[5lds]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5lds]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LDS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LDS FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Membrane_alanyl_aminopeptidase Membrane alanyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.2 3.4.11.2] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lds FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lds OCA], [http://pdbe.org/5lds PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lds RCSB], [http://www.ebi.ac.uk/pdbsum/5lds PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lds ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/AMPN_PIG AMPN_PIG]] Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May be involved in the metabolism of regulatory peptides of diverse cell types, responsible for the processing of peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines and involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis (By similarity). It is able to degrade Leu-enkephalin and Met-enkephalin but not cholecystokinin CCK8, neuromedin C (GRP-10), somatostatin-14, substance P and vasoactive intestinal peptide. In case of porcine transmissible gastroenteritis coronavirus (TGEV) and porcine respiratory coronavirus (PRCoV) infections, serves as a receptor for TGEV and PRCoV spike glycoprotein in a species-specific manner.<ref>PMID:7913510</ref> <ref>PMID:1350661</ref> <ref>PMID:7911642</ref> <ref>PMID:8985407</ref> <ref>PMID:9634079</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Membrane alanyl aminopeptidase]] | ||
| + | [[Category: Casasnovas, J M]] | ||
| + | [[Category: Mudgal, G]] | ||
[[Category: Reguera, J]] | [[Category: Reguera, J]] | ||
| - | [[Category: Casasnovas, J.M]] | ||
| - | [[Category: Mudgal, G]] | ||
[[Category: Santiago, C]] | [[Category: Santiago, C]] | ||
| + | [[Category: Aminopeptidase]] | ||
| + | [[Category: Cd13]] | ||
| + | [[Category: Coronavirus]] | ||
| + | [[Category: Enzime]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Papn]] | ||
| + | [[Category: Receptor]] | ||
Revision as of 13:27, 5 April 2017
Structure of the porcine aminopeptidase N ectodomain
| |||||||||||
