5m8s
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human tyrosinase related protein 1 mutant (T391V-R374S-Y362F) in complex with phenylthiourea (PTU)== | |
| - | + | <StructureSection load='5m8s' size='340' side='right' caption='[[5m8s]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5m8s]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M8S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5M8S FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=URS:N-PHENYLTHIOUREA'>URS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5m8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m8s OCA], [http://pdbe.org/5m8s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m8s RCSB], [http://www.ebi.ac.uk/pdbsum/5m8s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m8s ProSAT]</span></td></tr> |
| - | [[ | + | </table> |
| - | [[Category: Dijkstra, B | + | == Disease == |
| + | [[http://www.uniprot.org/uniprot/TYRP1_HUMAN TYRP1_HUMAN]] Oculocutaneous albinism type 3. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TYRP1_HUMAN TYRP1_HUMAN]] Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin.[UniProtKB:P07147] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Dijkstra, B W]] | ||
[[Category: Lai, X]] | [[Category: Lai, X]] | ||
[[Category: Soler-Lopez, M]] | [[Category: Soler-Lopez, M]] | ||
| + | [[Category: Wichers, H J]] | ||
| + | [[Category: Human tyrosinase related protein 1]] | ||
| + | [[Category: Melanin biosynthesis]] | ||
| + | [[Category: Oxidoreductase]] | ||
| + | [[Category: Tyrosinase]] | ||
| + | [[Category: Unknown function]] | ||
Revision as of 05:49, 31 January 2018
Crystal structure of human tyrosinase related protein 1 mutant (T391V-R374S-Y362F) in complex with phenylthiourea (PTU)
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