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5mtk
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human Caspase-1 with (3S,6S,10aS)-N-((2S,3S)-2-hydroxy-5-oxotetrahydrofuran-3-yl)-6-(isoquinoline-1-carboxamido)-5-oxodecahydropyrrolo[1,2-a]azocine-3-carboxamide (PGE-3935199)== | |
| - | + | <StructureSection load='5mtk' size='340' side='right' caption='[[5mtk]], [[Resolution|resolution]] 2.53Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5mtk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MTK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MTK FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=N7N:(3~{S})-3-[[(3~{S},6~{S},10~{a}~{S})-6-(isoquinolin-1-ylcarbonylamino)-5-oxidanylidene-2,3,6,7,8,9,10,10~{a}-octahydro-1~{H}-pyrrolo[1,2-a]azocin-3-yl]carbonylamino]-4-oxidanyl-butanoic+acid'>N7N</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-1 Caspase-1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.36 3.4.22.36] </span></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mtk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mtk OCA], [http://pdbe.org/5mtk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mtk RCSB], [http://www.ebi.ac.uk/pdbsum/5mtk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mtk ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CASP1_HUMAN CASP1_HUMAN]] Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.<ref>PMID:7876192</ref> <ref>PMID:15498465</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Caspase-1]] | ||
| + | [[Category: Brethon, A]] | ||
| + | [[Category: Chantalat, L]] | ||
| + | [[Category: Christin, O]] | ||
[[Category: Clary, L]] | [[Category: Clary, L]] | ||
| - | [[Category: | + | [[Category: Fournier, J F]] |
| + | [[Category: Gastreich, M]] | ||
| + | [[Category: Harris, C]] | ||
| + | [[Category: Isabet, T]] | ||
| + | [[Category: Pascau, J]] | ||
[[Category: Roche, D]] | [[Category: Roche, D]] | ||
| - | [[Category: Isabet, T]] | ||
| - | [[Category: Harris, C]] | ||
| - | [[Category: Brethon, A]] | ||
| - | [[Category: Gastreich, M]] | ||
[[Category: Rodeschin, V]] | [[Category: Rodeschin, V]] | ||
| - | [[Category: | + | [[Category: Thoreau, E]] |
| - | [[Category: | + | [[Category: Hydrolase]] |
| - | [[Category: | + | [[Category: Inflammatory disease]] |
| + | [[Category: Nanomolar inhibitor]] | ||
| + | [[Category: Sp3 hybridization]] | ||
Revision as of 06:13, 28 February 2018
Crystal structure of human Caspase-1 with (3S,6S,10aS)-N-((2S,3S)-2-hydroxy-5-oxotetrahydrofuran-3-yl)-6-(isoquinoline-1-carboxamido)-5-oxodecahydropyrrolo[1,2-a]azocine-3-carboxamide (PGE-3935199)
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