5mzr
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==X-ray structure of the H235Q mutant of GLIC in complex with propofol== | |
| - | + | <StructureSection load='5mzr' size='340' side='right' caption='[[5mzr]], [[Resolution|resolution]] 2.65Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5mzr]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MZR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MZR FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PFL:2,6-BIS(1-METHYLETHYL)PHENOL'>PFL</scene>, <scene name='pdbligand=PLC:DIUNDECYL+PHOSPHATIDYL+CHOLINE'>PLC</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mzr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mzr OCA], [http://pdbe.org/5mzr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mzr RCSB], [http://www.ebi.ac.uk/pdbsum/5mzr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mzr ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GLIC_GLOVI GLIC_GLOVI]] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Delarue, M]] | ||
[[Category: Fourati, Z]] | [[Category: Fourati, Z]] | ||
| - | [[Category: | + | [[Category: Membrane protein]] |
| + | [[Category: Transport protein]] | ||
Revision as of 06:22, 15 February 2018
X-ray structure of the H235Q mutant of GLIC in complex with propofol
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