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1soa

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[[Image:1soa.gif|left|200px]]
[[Image:1soa.gif|left|200px]]
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{{Structure
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{{STRUCTURE_1soa| PDB=1soa | SCENE= }}
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|RELATEDENTRY=[[1p5f|1P5F]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1soa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1soa OCA], [http://www.ebi.ac.uk/pdbsum/1soa PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1soa RCSB]</span>
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'''Human DJ-1 with sulfinic acid'''
'''Human DJ-1 with sulfinic acid'''
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[[Category: Ringe, D.]]
[[Category: Ringe, D.]]
[[Category: Wilson, M A.]]
[[Category: Wilson, M A.]]
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[[Category: dj-1/thij/pfpi familiy]]
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[[Category: Dj-1/thij/pfpi familiy]]
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[[Category: parkinson's disease]]
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[[Category: Parkinson's disease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:56:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:44:48 2008''
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Revision as of 05:56, 3 May 2008

Image:1soa.gif

Template:STRUCTURE 1soa

Human DJ-1 with sulfinic acid


Overview

Loss-of-function DJ-1 mutations can cause early-onset Parkinson's disease. The function of DJ-1 is unknown, but an acidic isoform accumulates after oxidative stress, leading to the suggestion that DJ-1 is protective under these conditions. We addressed whether this represents a posttranslational modification at cysteine residues by systematically mutating cysteine residues in human DJ-1. WT or C53A DJ-1 was readily oxidized in cultured cells, generating a pI 5.8 isoform, but an artificial C106A mutant was not. We observed a cysteine-sulfinic acid at C106 in crystalline DJ-1 but no modification of C53 or C46. Oxidation of DJ-1 was promoted by the crystallization procedure. In addition, oxidation-induced mitochondrial relocalization of DJ-1 and protection against cell death were abrogated in C106A but not C53A or C46A. We suggest that DJ-1 protects against neuronal death, and that this is signaled by acidification of the key cysteine residue, C106.

About this Structure

1SOA is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization., Canet-Aviles RM, Wilson MA, Miller DW, Ahmad R, McLendon C, Bandyopadhyay S, Baptista MJ, Ringe D, Petsko GA, Cookson MR, Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):9103-8. Epub 2004 Jun 4. PMID:15181200 Page seeded by OCA on Sat May 3 08:56:53 2008

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