5n2m
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the first bromodomain of human BRD4 in complex with a tetrahydroquinoline analogue== | |
| - | + | <StructureSection load='5n2m' size='340' side='right' caption='[[5n2m]], [[Resolution|resolution]] 1.54Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5n2m]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N2M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5N2M FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8J2:propan-2-yl+~{N}-[(2~{S},4~{R})-6-(3-acetamidophenyl)-1-ethanoyl-2-methyl-3,4-dihydro-2~{H}-quinolin-4-yl]carbamate'>8J2</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5n2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n2m OCA], [http://pdbe.org/5n2m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5n2m RCSB], [http://www.ebi.ac.uk/pdbsum/5n2m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5n2m ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Arrowsmith, C H]] | ||
| + | [[Category: Bharatham, N]] | ||
| + | [[Category: Bountra, C]] | ||
| + | [[Category: Boyd, V A]] | ||
[[Category: Chai, S]] | [[Category: Chai, S]] | ||
| - | [[Category: | + | [[Category: Chen, T]] |
| - | [[Category: | + | [[Category: Delft, F von]] |
| - | [[Category: | + | [[Category: Edwards, A M]] |
| - | + | ||
[[Category: Fedorov, O]] | [[Category: Fedorov, O]] | ||
| - | [[Category: | + | [[Category: Guy, R K]] |
| + | [[Category: Heroven, C]] | ||
| + | [[Category: Knapp, S]] | ||
| + | [[Category: Krojer, T]] | ||
| + | [[Category: Lee, R E]] | ||
[[Category: Picaud, S]] | [[Category: Picaud, S]] | ||
| - | [[Category: Shadrick, W | + | [[Category: Structural genomic]] |
| + | [[Category: Shadrick, W R]] | ||
| + | [[Category: Shelat, A A]] | ||
[[Category: Siejka, P]] | [[Category: Siejka, P]] | ||
| - | [[Category: | + | [[Category: Slavish, P J]] |
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[[Category: Tallant, C]] | [[Category: Tallant, C]] | ||
| - | [[Category: | + | [[Category: Wiggers, H J]] |
| - | + | [[Category: Young, B M]] | |
| - | [[Category: Young, B | + | [[Category: Sgc]] |
| - | [[Category: | + | [[Category: Transcription]] |
| - | [[Category: | + | |
Revision as of 06:15, 28 February 2018
Crystal structure of the first bromodomain of human BRD4 in complex with a tetrahydroquinoline analogue
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Categories: Arrowsmith, C H | Bharatham, N | Bountra, C | Boyd, V A | Chai, S | Chen, T | Delft, F von | Edwards, A M | Fedorov, O | Guy, R K | Heroven, C | Knapp, S | Krojer, T | Lee, R E | Picaud, S | Structural genomic | Shadrick, W R | Shelat, A A | Siejka, P | Slavish, P J | Tallant, C | Wiggers, H J | Young, B M | Sgc | Transcription
