1sr5

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[[Image:1sr5.jpg|left|200px]]
[[Image:1sr5.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1sr5 |SIZE=350|CAPTION= <scene name='initialview01'>1sr5</scene>, resolution 3.10&Aring;
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The line below this paragraph, containing "STRUCTURE_1sr5", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NT1:HEPARIN+HEPTASACCHARIDE'>NT1</scene>, <scene name='pdbligand=NT2:2,3,4,6-TETRA-O-SULFOHEXOPYRANOSE'>NT2</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Thrombin Thrombin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1sr5| PDB=1sr5 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sr5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sr5 OCA], [http://www.ebi.ac.uk/pdbsum/1sr5 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1sr5 RCSB]</span>
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}}
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'''ANTITHROMBIN-ANHYDROTHROMBIN-HEPARIN TERNARY COMPLEX STRUCTURE'''
'''ANTITHROMBIN-ANHYDROTHROMBIN-HEPARIN TERNARY COMPLEX STRUCTURE'''
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[[Category: Gettins, P G.]]
[[Category: Gettins, P G.]]
[[Category: Petitou, M.]]
[[Category: Petitou, M.]]
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[[Category: antithrombin activation by hep anhydrothrombin]]
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[[Category: Antithrombin activation by hep anhydrothrombin]]
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[[Category: protein-protein interaction]]
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[[Category: Protein-protein interaction]]
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[[Category: serine proteinase inhibitor]]
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[[Category: Serine proteinase inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:03:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:45:56 2008''
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Revision as of 06:03, 3 May 2008

Image:1sr5.jpg

Template:STRUCTURE 1sr5

ANTITHROMBIN-ANHYDROTHROMBIN-HEPARIN TERNARY COMPLEX STRUCTURE


Overview

Antithrombin, the principal physiological inhibitor of the blood coagulation proteinase thrombin, requires heparin as a cofactor. We report the crystal structure of the rate-determining encounter complex formed between antithrombin, anhydrothrombin and an optimal synthetic 16-mer oligosaccharide. The antithrombin reactive center loop projects from the serpin body and adopts a canonical conformation that makes extensive backbone and side chain contacts from P5 to P6' with thrombin's restrictive specificity pockets, including residues in the 60-loop. These contacts rationalize many earlier mutagenesis studies on thrombin specificity. The 16-mer oligosaccharide is just long enough to form the predicted bridge between the high-affinity pentasaccharide-binding site on antithrombin and the highly basic exosite 2 on thrombin, validating the design strategy for this synthetic heparin. The protein-protein and protein-oligosaccharide interactions together explain the basis for heparin activation of antithrombin as a thrombin inhibitor.

About this Structure

1SR5 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The ternary complex of antithrombin-anhydrothrombin-heparin reveals the basis of inhibitor specificity., Dementiev A, Petitou M, Herbert JM, Gettins PG, Nat Struct Mol Biol. 2004 Sep;11(9):863-7. Epub 2004 Aug 15. PMID:15311268 Page seeded by OCA on Sat May 3 09:03:03 2008

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