1ss6

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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ss6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ss6 OCA], [http://www.ebi.ac.uk/pdbsum/1ss6 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ss6 RCSB]</span>
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'''Solution structure of SEP domain from human p47'''
'''Solution structure of SEP domain from human p47'''
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[[Category: Sievert, V.]]
[[Category: Sievert, V.]]
[[Category: Soukenik, M.]]
[[Category: Soukenik, M.]]
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[[Category: nmr]]
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[[Category: Nmr]]
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[[Category: p47]]
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[[Category: P47]]
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[[Category: sep]]
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[[Category: Sep]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:04:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:46:16 2008''
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Revision as of 06:04, 3 May 2008

Image:1ss6.gif

Template:STRUCTURE 1ss6

Solution structure of SEP domain from human p47


Overview

The solution structure of the human p47 SEP domain in a construct comprising residues G1-S2-p47(171-270) was determined by NMR spectroscopy. A structure-derived hypothesis about the domains' function was formulated and pursued in binding experiments with cysteine proteases. The SEP domain was found to be a reversible competitive inhibitor of cathepsin L with a Ki of 1.5 microM. The binding of G1-S2-p47(171-270) to cathepsin L was mapped by biochemical assays and the binding interface was investigated by NMR chemical shift perturbation experiments.

About this Structure

1SS6 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The SEP domain of p47 acts as a reversible competitive inhibitor of cathepsin L., Soukenik M, Diehl A, Leidert M, Sievert V, Bussow K, Leitner D, Labudde D, Ball LJ, Lechner A, Nagler DK, Oschkinat H, FEBS Lett. 2004 Oct 22;576(3):358-62. PMID:15498563 Page seeded by OCA on Sat May 3 09:04:46 2008

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