1st0

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[[Image:1st0.jpg|left|200px]]
[[Image:1st0.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1st0 |SIZE=350|CAPTION= <scene name='initialview01'>1st0</scene>, resolution 1.9&Aring;
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The line below this paragraph, containing "STRUCTURE_1st0", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=GTG:7-METHYL-GUANOSINE-5&#39;-TRIPHOSPHATE-5&#39;-GUANOSINE'>GTG</scene>, <scene name='pdbligand=YT3:YTTRIUM+(III)+ION'>YT3</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= DCPS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_1st0| PDB=1st0 | SCENE= }}
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|RELATEDENTRY=[[1st4|1ST4]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1st0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1st0 OCA], [http://www.ebi.ac.uk/pdbsum/1st0 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1st0 RCSB]</span>
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}}
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'''Structure of DcpS bound to m7GpppG'''
'''Structure of DcpS bound to m7GpppG'''
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[[Category: Liu, H.]]
[[Category: Liu, H.]]
[[Category: Liu, S W.]]
[[Category: Liu, S W.]]
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[[Category: cap]]
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[[Category: Cap]]
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[[Category: decapping]]
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[[Category: Decapping]]
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[[Category: exosome]]
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[[Category: Exosome]]
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[[Category: hit protein]]
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[[Category: Hit protein]]
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[[Category: messenger rna]]
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[[Category: Messenger rna]]
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[[Category: mrna]]
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[[Category: Mrna]]
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[[Category: rna decay]]
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[[Category: Rna decay]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:06:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:46:35 2008''
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Revision as of 06:06, 3 May 2008

Image:1st0.jpg

Template:STRUCTURE 1st0

Structure of DcpS bound to m7GpppG


Overview

Complete removal of residual N-7 guanine cap from degraded messenger RNA is necessary to prevent accumulation of intermediates that might interfere with RNA processing, export, and translation. The human scavenger decapping enzyme, DcpS, catalyzes residual cap hydrolysis following mRNA degradation, releasing N-7 methyl guanosine monophosphate and 5'-diphosphate terminated cap or mRNA products. DcpS structures bound to m(7)GpppG or m(7)GpppA reveal an asymmetric DcpS dimer that simultaneously creates an open nonproductive DcpS-cap complex and a closed productive DcpS-cap complex that alternate via 30 A domain movements. Structural and biochemical analysis suggests an autoregulatory mechanism whereby premature decapping mRNA is prevented by blocking the conformational changes that are required to form a closed productive active site capable of cap hydrolysis.

About this Structure

1ST0 is a Single protein structure of sequence from Homo sapiens. The following page contains interesting information on the relation of 1ST0 with [Exosomes]. Full crystallographic information is available from OCA.

Reference

Insights into the structure, mechanism, and regulation of scavenger mRNA decapping activity., Gu M, Fabrega C, Liu SW, Liu H, Kiledjian M, Lima CD, Mol Cell. 2004 Apr 9;14(1):67-80. PMID:15068804 Page seeded by OCA on Sat May 3 09:06:27 2008

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OCA

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