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5php
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==PanDDA analysis group deposition -- Crystal Structure of JMJD2D after initial refinement with no ligand modelled (structure 2)== | |
| - | + | <StructureSection load='5php' size='340' side='right' caption='[[5php]], [[Resolution|resolution]] 1.72Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5php]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5PHP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5PHP FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=OGA:N-OXALYLGLYCINE'>OGA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5php FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5php OCA], [http://pdbe.org/5php PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5php RCSB], [http://www.ebi.ac.uk/pdbsum/5php PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5php ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/KDM4D_HUMAN KDM4D_HUMAN]] Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.<ref>PMID:16603238</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Arrowsmith, C H]] | ||
| + | [[Category: Bountra, C]] | ||
| + | [[Category: Bradley, A R]] | ||
| + | [[Category: Brandao-Neto, J]] | ||
| + | [[Category: Brennan, P E]] | ||
| + | [[Category: Burgess-Brown, N]] | ||
| + | [[Category: Collins, P]] | ||
| + | [[Category: Cox, O]] | ||
| + | [[Category: Delft, F von]] | ||
| + | [[Category: Dias, A]] | ||
| + | [[Category: Douangamath, A]] | ||
| + | [[Category: Edwards, A]] | ||
| + | [[Category: Fairhead, M]] | ||
[[Category: Krojer, T]] | [[Category: Krojer, T]] | ||
| + | [[Category: MacLean, E]] | ||
| + | [[Category: Ng, J]] | ||
| + | [[Category: Oppermann, U]] | ||
| + | [[Category: Pearce, N M]] | ||
| + | [[Category: Renjie, Z]] | ||
| + | [[Category: Sethi, R]] | ||
| + | [[Category: Szykowska, A]] | ||
| + | [[Category: Talon, R]] | ||
| + | [[Category: Vollmar, M]] | ||
| + | [[Category: Wright, N]] | ||
| + | [[Category: Epigenetic]] | ||
| + | [[Category: Jmj domain]] | ||
| + | [[Category: Oxidoreductase]] | ||
| + | [[Category: Pandda]] | ||
| + | [[Category: Sgc - diamond i04-1 fragment screening]] | ||
Revision as of 21:24, 15 March 2017
PanDDA analysis group deposition -- Crystal Structure of JMJD2D after initial refinement with no ligand modelled (structure 2)
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Categories: Arrowsmith, C H | Bountra, C | Bradley, A R | Brandao-Neto, J | Brennan, P E | Burgess-Brown, N | Collins, P | Cox, O | Delft, F von | Dias, A | Douangamath, A | Edwards, A | Fairhead, M | Krojer, T | MacLean, E | Ng, J | Oppermann, U | Pearce, N M | Renjie, Z | Sethi, R | Szykowska, A | Talon, R | Vollmar, M | Wright, N | Epigenetic | Jmj domain | Oxidoreductase | Pandda | Sgc - diamond i04-1 fragment screening
